HCSGD entry for TCF7L1

1. General information

Official gene symbolTCF7L1
Entrez ID83439
Gene full nametranscription factor 7-like 1 (T-cell specific, HMG-box)
Other gene symbolsTCF-3 TCF3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingIEA NASmolecular_function
GO:0003682Chromatin bindingIBA IEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEA NASmolecular_function
GO:0005634NucleusIEA NAScellular_component
GO:0005667Transcription factor complexIBAcellular_component
GO:0006325Chromatin organizationNASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIBAbiological_process
GO:0007420Brain developmentIBAbiological_process
GO:0008013Beta-catenin bindingIBA IEAmolecular_function
GO:0008595Anterior/posterior axis specification, embryoIEAbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0030111Regulation of Wnt signaling pathwayNASbiological_process
GO:0035019Somatic stem cell maintenanceIEAbiological_process
GO:0043565Sequence-specific DNA bindingIBAmolecular_function
GO:0043588Skin developmentIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIBAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIEAbiological_process
GO:0046022Positive regulation of transcription from RNA polymerase II promoter during mitosisIEAbiological_process
GO:0048319Axial mesoderm morphogenesisIEAbiological_process
GO:0048699Generation of neuronsIBAbiological_process
GO:0060070Canonical Wnt signaling pathwayIBAbiological_process
GO:2000036Regulation of stem cell maintenanceIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99246823450.00149571440.99999024730.0751311069

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.0216360610
GSE13712_SHEARDown-1.2804497367
GSE13712_STATICDown-0.6624332954
GSE19018Up0.0676481019
GSE19899_A1Down-1.1622951107
GSE19899_A2Down-1.3950023662
PubMed_21979375_A1Up0.0882795447
PubMed_21979375_A2Down-0.3840286163
GSE35957Up0.1811330090
GSE36640Down-0.9418954077
GSE54402Down-0.8656447527
GSE9593Down-1.0716293634
GSE43922Down-0.6641071193
GSE24585Up0.0518879991
GSE37065Down-0.2360353544
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.1112002228

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-429MIMAT0001536MIRT016640Reporter assayFunctional MTI20005803
hsa-miR-200a-3pMIMAT0000682MIRT020351Reporter assayFunctional MTI20005803
hsa-miR-200c-3pMIMAT0000617MIRT021073Reporter assayFunctional MTI20005803
hsa-miR-141-3pMIMAT0000432MIRT021652Reporter assayFunctional MTI20005803
hsa-miR-200b-3pMIMAT0000318MIRT024127Reporter assayFunctional MTI20005803
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18258400CD9 antigen, MHC class I chain-related sequence A (MICA) and cell division cycle 37 homolog (CDC37) were up-regulated, and bone morphogenetic protein 4 (BMP4), dickkopf-1 (DKK1), and transcription factor 7-like 1 (TCF7L1) were down-regulated in old cells
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