HCSGD entry for FZD8
1. General information
| Official gene symbol | FZD8 |
|---|---|
| Entrez ID | 8325 |
| Gene full name | frizzled family receptor 8 |
| Other gene symbols | FZ-8 hFZ8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001944 | Vasculature development | IBA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0005102 | Receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IBA | cellular_component |
| GO:0007409 | Axonogenesis | IBA | biological_process |
| GO:0007420 | Brain development | IBA | biological_process |
| GO:0008406 | Gonad development | IBA | biological_process |
| GO:0009790 | Embryo development | IBA | biological_process |
| GO:0016021 | Integral component of membrane | TAS | cellular_component |
| GO:0017147 | Wnt-protein binding | IBA | molecular_function |
| GO:0030165 | PDZ domain binding | IPI | molecular_function |
| GO:0030182 | Neuron differentiation | ISS | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0033077 | T cell differentiation in thymus | IBA | biological_process |
| GO:0042813 | Wnt-activated receptor activity | IBA TAS | molecular_function |
| GO:0042995 | Cell projection | IBA | cellular_component |
| GO:0043507 | Positive regulation of JUN kinase activity | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0060070 | Canonical Wnt signaling pathway | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000953231 | 0.9999584704 | 0.0277752688 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | Up | 2.4691641765 |
| GSE24585 | Up | 0.3428948551 |
| GSE37065 | Up | 0.5870009945 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 1.1287893570 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT007255 | Luciferase reporter assay | Functional MTI | 23393589 |
| hsa-miR-375 | MIMAT0000728 | MIRT007255 | Luciferase reporter assay | Functional MTI | 23396279 |
| hsa-miR-374b-5p | MIMAT0004955 | MIRT016029 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018441 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051873 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
