HCSGD entry for FZD4
1. General information
| Official gene symbol | FZD4 |
|---|---|
| Entrez ID | 8322 |
| Gene full name | frizzled family receptor 4 |
| Other gene symbols | CD344 EVR1 FEVR FZD4S Fz-4 Fz4 FzE4 GPCR hFz4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001570 | Vasculogenesis | IBA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IC | cellular_component |
| GO:0005911 | Cell-cell junction | IEA | cellular_component |
| GO:0007223 | Wnt signaling pathway, calcium modulating pathway | IDA | biological_process |
| GO:0007420 | Brain development | IBA | biological_process |
| GO:0007605 | Sensory perception of sound | IEA | biological_process |
| GO:0009790 | Embryo development | IBA | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0010812 | Negative regulation of cell-substrate adhesion | IMP | biological_process |
| GO:0016055 | Wnt signaling pathway | IDA | biological_process |
| GO:0017147 | Wnt-protein binding | IBA | molecular_function |
| GO:0019955 | Cytokine binding | IPI | molecular_function |
| GO:0030165 | PDZ domain binding | IDA IPI | molecular_function |
| GO:0030182 | Neuron differentiation | ISS | biological_process |
| GO:0030947 | Regulation of vascular endothelial growth factor receptor signaling pathway | IBA | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0031987 | Locomotion involved in locomotory behavior | IEA | biological_process |
| GO:0034446 | Substrate adhesion-dependent cell spreading | IBA | biological_process |
| GO:0035426 | Extracellular matrix-cell signaling | IEA | biological_process |
| GO:0042701 | Progesterone secretion | IBA | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0042813 | Wnt-activated receptor activity | IDA | molecular_function |
| GO:0042995 | Cell projection | IBA | cellular_component |
| GO:0043507 | Positive regulation of JUN kinase activity | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IPI | molecular_function |
| GO:0051091 | Positive regulation of sequence-specific DNA binding transcription factor activity | IDA | biological_process |
| GO:0060070 | Canonical Wnt signaling pathway | IDA | biological_process |
| GO:0061299 | Retina vasculature morphogenesis in camera-type eye | IMP | biological_process |
| GO:0061301 | Cerebellum vasculature morphogenesis | IEA | biological_process |
| GO:0061304 | Retinal blood vessel morphogenesis | IEA | biological_process |
| GO:0071300 | Cellular response to retinoic acid | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0718199195 | 0.2219490559 | 0.5715393848 | 0.9058646457 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1763339539 |
| GSE13712_SHEAR | Up | 0.7093844136 |
| GSE13712_STATIC | Up | 0.4393720908 |
| GSE19018 | Up | 0.1761113494 |
| GSE19899_A1 | Up | 0.2381528565 |
| GSE19899_A2 | Up | 0.0801217687 |
| PubMed_21979375_A1 | Down | -1.3136655744 |
| PubMed_21979375_A2 | Up | 0.0376069541 |
| GSE35957 | Up | 0.8665567383 |
| GSE36640 | Up | 0.7299338848 |
| GSE54402 | Down | -0.0522572376 |
| GSE9593 | Down | -0.5084625309 |
| GSE43922 | Up | 0.0485313400 |
| GSE24585 | Down | -0.2149356390 |
| GSE37065 | Up | 0.0985314096 |
| GSE28863_A1 | Up | 0.4098957247 |
| GSE28863_A2 | Down | -0.6020425346 |
| GSE28863_A3 | Down | -0.2374740838 |
| GSE28863_A4 | Up | 0.2608895690 |
| GSE48662 | Down | -0.1650606172 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019965 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024639 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026574 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030528 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046072 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
