HCSGD entry for EOMES

1. General information

Official gene symbolEOMES
Entrez ID8320
Gene full nameeomesodermin
Other gene symbolsTBR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIEAmolecular_function
GO:0001102RNA polymerase II activating transcription factor bindingISSmolecular_function
GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptionISSmolecular_function
GO:0001706Endoderm formationISSbiological_process
GO:0001707Mesoderm formationISSbiological_process
GO:0001714Endodermal cell fate specificationIEAbiological_process
GO:0001829Trophectodermal cell differentiationIEAbiological_process
GO:0002302CD8-positive, alpha-beta T cell differentiation involved in immune responseIMPbiological_process
GO:0003677DNA bindingIEA ISSmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0007420Brain developmentIMPbiological_process
GO:0010002Cardioblast differentiationIEAbiological_process
GO:0019827Stem cell maintenanceIEAbiological_process
GO:0021772Olfactory bulb developmentIEAbiological_process
GO:0021796Cerebral cortex regionalizationIEAbiological_process
GO:0021895Cerebral cortex neuron differentiationIEAbiological_process
GO:0032609Interferon-gamma productionIEAbiological_process
GO:0035914Skeletal muscle cell differentiationIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0045597Positive regulation of cell differentiationIEAbiological_process
GO:0045664Regulation of neuron differentiationIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0060706Cell differentiation involved in embryonic placenta developmentISSbiological_process
GO:0060809Mesodermal to mesenchymal transition involved in gastrulationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57458552870.82526906650.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0242700035
GSE13712_SHEARDown-0.1844391852
GSE13712_STATICUp0.0345323639
GSE19018Down-0.1720001730
GSE19899_A1Up0.2281607656
GSE19899_A2Up0.1637306870
PubMed_21979375_A1Down-0.0837561396
PubMed_21979375_A2Down-0.0184289687
GSE35957Up0.0682229823
GSE36640Down-0.0133027311
GSE54402Up0.1221327466
GSE9593Up0.1598923211
GSE43922Up0.0377930770
GSE24585Down-0.1238493326
GSE37065Up0.0572872023
GSE28863_A1Down-0.0874370575
GSE28863_A2Up0.0419031705
GSE28863_A3Up0.2519570408
GSE28863_A4Up0.1053023527
GSE48662Down-0.0736588131

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-106b-5pMIMAT0000680MIRT006568Luciferase reporter assayFunctional MTI20709030
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

16204645Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells
16204645In CD8+ T cells and NK cells, the transcription factors T-bet and eomesodermin (Eomes) regulate maturation and effector functions, including IFN-gamma production
16204645As Eomes null mice are not viable, real-time polymerase chain reaction comparisons between C57Bl/6J (B6) and alymphoid (Rag2(0/0)gammac0/0) mice were used to assess uNK cell expression of T-bet, Eomes, and the target genes IFN-gamma, granzyme A, and perforin
16204645In uterus, Eomes transcripts greatly outnumbered those of T-bet, whether donors were nonpregnant or pregnant, and increased to gd10
16204645In uNK cells, transcripts for T-bet, Eomes, and IFN-gamma were most abundant in mature stage cells, and transcripts for granzyme A and perforin were lower at this stage than in immature or senescent cells
16204645Thus, Eomes dominance to T-bet discriminates regulation of the uNK cell subset from that observed for peripheral NK cells
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