HCSGD entry for AXIN2

1. General information

Official gene symbolAXIN2
Entrez ID8313
Gene full nameaxin 2
Other gene symbolsAXIL ODCRCS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001756SomitogenesisIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIMPbiological_process
GO:0001957Intramembranous ossificationIBA IEAbiological_process
GO:0003413Chondrocyte differentiation involved in endochondral bone morphogenesisIEAbiological_process
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005096GTPase activator activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005813CentrosomeIDA IEAcellular_component
GO:0005881Cytoplasmic microtubuleIBAcellular_component
GO:0005886Plasma membraneIBAcellular_component
GO:0005938Cell cortexIBAcellular_component
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0008013Beta-catenin bindingIBA NASmolecular_function
GO:0008283Cell proliferationIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEA IMPbiological_process
GO:0009950Dorsal/ventral axis specificationIBAbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIMPbiological_process
GO:0010942Positive regulation of cell deathIMPbiological_process
GO:0014069Postsynaptic densityIBAcellular_component
GO:0016023Cytoplasmic membrane-bounded vesicleIBAcellular_component
GO:0019899Enzyme bindingIPImolecular_function
GO:0019901Protein kinase bindingIBAmolecular_function
GO:0030111Regulation of Wnt signaling pathwayIEAbiological_process
GO:0030282Bone mineralizationIEAbiological_process
GO:0030877Beta-catenin destruction complexNAScellular_component
GO:0031625Ubiquitin protein ligase bindingIEA IPImolecular_function
GO:0032423Regulation of mismatch repairIMPbiological_process
GO:0034613Cellular protein localizationIDAbiological_process
GO:0035414Negative regulation of catenin import into nucleusIMPbiological_process
GO:0038032Termination of G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0042476OdontogenesisIMPbiological_process
GO:0043085Positive regulation of catalytic activityIBAbiological_process
GO:0043547Positive regulation of GTPase activityIBAbiological_process
GO:0043570Maintenance of DNA repeat elementsIMPbiological_process
GO:0045668Negative regulation of osteoblast differentiationIBA IEAbiological_process
GO:0048255MRNA stabilizationIMPbiological_process
GO:0050790Regulation of catalytic activityIBAbiological_process
GO:0061181Regulation of chondrocyte developmentIEAbiological_process
GO:0070016Armadillo repeat domain bindingIBAmolecular_function
GO:0070411I-SMAD bindingIEAmolecular_function
GO:0070602Regulation of centromeric sister chromatid cohesionIEA IMPbiological_process
GO:0071407Cellular response to organic cyclic compoundIBAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDA IMPbiological_process
GO:0090244Wnt signaling pathway involved in somitogenesisIBAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.58366448840.86832542460.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0499611875
GSE13712_SHEARDown-0.0634157227
GSE13712_STATICUp0.0596079318
GSE19018Down-0.0143082458
GSE19899_A1Up0.0859719665
GSE19899_A2Down-0.0446582394
PubMed_21979375_A1Up0.0609670348
PubMed_21979375_A2Down-0.0314040937
GSE35957Down-0.0534151574
GSE36640Down-0.0657345060
GSE54402Up0.0822793306
GSE9593Down-0.0088526923
GSE43922Up0.0233646858
GSE24585Down-0.0440233391
GSE37065Down-0.0094780122
GSE28863_A1Up0.6082629147
GSE28863_A2Up0.1787826132
GSE28863_A3Up0.1907546482
GSE28863_A4Up0.1064199223
GSE48662Down-0.0934083377

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT001232Luciferase reporter assayFunctional MTI19336450
hsa-miR-16-5pMIMAT0000069MIRT006751SequencingFunctional MTI (Weak)20371350
hsa-miR-103a-3pMIMAT0000101MIRT027137SequencingFunctional MTI (Weak)20371350
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-34a-5pMIMAT00002551hsa-miR-34a19336450
hsa-miR-34a-5pMIMAT00002552hsa-miR-34a19336450
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.