HCSGD entry for CAPNS1
1. General information
| Official gene symbol | CAPNS1 |
|---|---|
| Entrez ID | 826 |
| Gene full name | calpain, small subunit 1 |
| Other gene symbols | 30K CALPAIN4 CANP CANPS CAPN4 CDPS CSS1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004198 | Calcium-dependent cysteine-type endopeptidase activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0008152 | Metabolic process | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6169131378 | 0.1967990578 | 0.9999902473 | 0.8586752237 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1228824878 |
| GSE13712_SHEAR | Down | -0.2765763721 |
| GSE13712_STATIC | Down | -0.2152762530 |
| GSE19018 | Up | 0.5504110936 |
| GSE19899_A1 | Down | -0.7735365412 |
| GSE19899_A2 | Up | 0.2852458070 |
| PubMed_21979375_A1 | Down | -0.1427535011 |
| PubMed_21979375_A2 | Down | -0.0153247088 |
| GSE35957 | Down | -0.1121294040 |
| GSE36640 | Down | -0.0483086911 |
| GSE54402 | Down | -0.0509823985 |
| GSE9593 | Up | 0.2293578370 |
| GSE43922 | Down | -0.3690556414 |
| GSE24585 | Down | -0.0118452410 |
| GSE37065 | Down | -0.2546895264 |
| GSE28863_A1 | Down | -0.2115252034 |
| GSE28863_A2 | Up | 0.0212787070 |
| GSE28863_A3 | Down | -0.2382904955 |
| GSE28863_A4 | Up | 0.0276829928 |
| GSE48662 | Up | 0.4159470328 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| PD150606 | DB02570 | EXPT01931 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023039 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037468 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038378 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039201 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041246 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-425-3p | MIMAT0001343 | MIRT042428 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044827 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047067 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048473 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048635 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20107320 | Here we show that CAPNS1 depletion impairs senescence induction both in BJ-ET H-Ras(v12) inducible human fibroblasts upon Ras induction and in HT1080 targeted to senescence by treatment with low doses of doxorubicin |
| 20107320 | We further show that CAPNS1 depletion is coupled to reduced levels of H2AX phosphorylation, not only in Ras(v12) induced BJ-ET fibroblasts, but also in a number of cellular systems upon genotoxic stress |
| 20107320 | In particular CAPNS1 depletion affects gamma-H2AX appearance or persistence in U2OS osteosarcoma cells 24 hours after MMC addition or UV light exposure; in HT1080 upon camptothecin treatment for 4 hours and 48 hours after addition of MMC; in MDA-MB-231, 24 hours after UV light exposure and 2 hours after bleomycin addition |
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