HCSGD entry for SMC1A
1. General information
| Official gene symbol | SMC1A |
|---|---|
| Entrez ID | 8243 |
| Gene full name | structural maintenance of chromosomes 1A |
| Other gene symbols | CDLS2 DXS423E SB1.8 SMC1 SMC1L1 SMC1alpha SMCB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000070 | Mitotic sister chromatid segregation | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | TAS | biological_process |
| GO:0000775 | Chromosome, centromeric region | TAS | cellular_component |
| GO:0000776 | Kinetochore | IDA | cellular_component |
| GO:0000777 | Condensed chromosome kinetochore | IEA | cellular_component |
| GO:0000794 | Condensed nuclear chromosome | TAS | cellular_component |
| GO:0003682 | Chromatin binding | IDA IEA | molecular_function |
| GO:0003777 | Microtubule motor activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005694 | Chromosome | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0007052 | Mitotic spindle organization | TAS | biological_process |
| GO:0007062 | Sister chromatid cohesion | IMP | biological_process |
| GO:0007064 | Mitotic sister chromatid cohesion | IEA TAS | biological_process |
| GO:0007093 | Mitotic cell cycle checkpoint | IDA | biological_process |
| GO:0007126 | Meiosis | ISS | biological_process |
| GO:0008278 | Cohesin complex | IEA | cellular_component |
| GO:0008280 | Cohesin core heterodimer | TAS | cellular_component |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0009314 | Response to radiation | IEP | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0019827 | Stem cell maintenance | IEA | biological_process |
| GO:0030893 | Meiotic cohesin complex | IDA | cellular_component |
| GO:0032876 | Negative regulation of DNA endoreduplication | IMP | biological_process |
| GO:0036033 | Mediator complex binding | IEA | molecular_function |
| GO:0042770 | Signal transduction in response to DNA damage | IDA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3295658068 | 0.1824774705 | 0.9999902473 | 0.8280917773 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1256110204 |
| GSE13712_SHEAR | Down | -0.0300453830 |
| GSE13712_STATIC | Up | 0.0815239730 |
| GSE19018 | Up | 0.0707066025 |
| GSE19899_A1 | Down | -0.0818842268 |
| GSE19899_A2 | Down | -0.5730151037 |
| PubMed_21979375_A1 | Down | -0.4291468438 |
| PubMed_21979375_A2 | Down | -0.1586327662 |
| GSE35957 | Down | -0.2973118337 |
| GSE36640 | Down | -1.5543627291 |
| GSE54402 | Down | -0.0730888410 |
| GSE9593 | Down | -0.2022355384 |
| GSE43922 | Down | -0.1168431907 |
| GSE24585 | Up | 0.1898211739 |
| GSE37065 | Down | -0.1809631505 |
| GSE28863_A1 | Up | 0.7042403007 |
| GSE28863_A2 | Up | 0.7379305791 |
| GSE28863_A3 | Up | 0.2823819849 |
| GSE28863_A4 | Up | 0.2533477492 |
| GSE48662 | Up | 0.4009674615 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7e-5p | MIMAT0000066 | MIRT004469 | Luciferase reporter assay//Reporter assay;Other | Functional MTI | 15131085 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT031051 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037710 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038730 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040012 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042579 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042788 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-328-3p | MIMAT0000752 | MIRT043786 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044450 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045613 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049569 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052108 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-let-7e-5p | MIMAT0000066 | 1 | hsa-let-7e | 15131085 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
