HCSGD entry for ZRSR2
1. General information
| Official gene symbol | ZRSR2 |
|---|---|
| Entrez ID | 8233 |
| Gene full name | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 |
| Other gene symbols | U2AF1-RS2 U2AF1L2 U2AF1RS2 URP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000245 | Spliceosomal complex assembly | IMP | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | IMP | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005689 | U12-type spliceosomal complex | IDA | cellular_component |
| GO:0008380 | RNA splicing | IC | biological_process |
| GO:0030628 | Pre-mRNA 3'-splice site binding | IDA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1231459481 | 0.2696468485 | 0.7175834625 | 0.9928540355 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4588391530 |
| GSE13712_SHEAR | Down | -0.0727875492 |
| GSE13712_STATIC | Up | 0.1965552247 |
| GSE19018 | Down | -0.1372676930 |
| GSE19899_A1 | Down | -0.0988712967 |
| GSE19899_A2 | Up | 0.9761147429 |
| PubMed_21979375_A1 | Down | -0.2857388531 |
| PubMed_21979375_A2 | Up | 0.1482532853 |
| GSE35957 | Down | -0.0815417688 |
| GSE36640 | Up | 0.3336774929 |
| GSE54402 | Up | 0.4254853339 |
| GSE9593 | Up | 0.4115629584 |
| GSE43922 | Up | 0.0328152156 |
| GSE24585 | Up | 0.0320593693 |
| GSE37065 | Up | 0.0923333615 |
| GSE28863_A1 | Down | -0.7989381315 |
| GSE28863_A2 | Down | -0.4299869070 |
| GSE28863_A3 | Down | -0.1107578350 |
| GSE28863_A4 | Down | -0.1817318364 |
| GSE48662 | Up | 0.1278689121 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27147278 | Prominent examples include aberrations in cytokines and their signaling pathways (such as tumor necrosis factor-alpha, interferon-gamma, SMAD proteins), mutations in genes encoding the RNA splicing machinery (SF3B1, SRSF2, ZRSR2, and U2AF1 genes), mutations in genes disrupting the epigenetic machinery (TET2, DNMT3A, DNMT3B, EZH2, ASXL1) |
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