HCSGD entry for MKKS

1. General information

Official gene symbolMKKS
Entrez ID8195
Gene full nameMcKusick-Kaufman syndrome
Other gene symbolsBBS6 HMCS KMS MKS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001103RNA polymerase II repressing transcription factor bindingIPImolecular_function
GO:0001947Heart loopingISSbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005622IntracellularIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006457Protein foldingTASbiological_process
GO:0007286Spermatid developmentISSbiological_process
GO:0007368Determination of left/right symmetryISSbiological_process
GO:0007507Heart developmentTASbiological_process
GO:0007601Visual perceptionIEAbiological_process
GO:0007608Sensory perception of smellISSbiological_process
GO:0008406Gonad developmentTASbiological_process
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0014824Artery smooth muscle contractionIEAbiological_process
GO:0021756Striatum developmentISSbiological_process
GO:0021766Hippocampus developmentISSbiological_process
GO:0021987Cerebral cortex developmentISSbiological_process
GO:0031514Motile ciliumISScellular_component
GO:0032402Melanosome transportISSbiological_process
GO:0035058Nonmotile primary cilium assemblyIEAbiological_process
GO:0035176Social behaviorISSbiological_process
GO:0038108Negative regulation of appetite by leptin-mediated signaling pathwayISSbiological_process
GO:0040018Positive regulation of multicellular organism growthIEAbiological_process
GO:0042311VasodilationIEAbiological_process
GO:0042384Cilium assemblyISSbiological_process
GO:0045444Fat cell differentiationISSbiological_process
GO:0045494Photoreceptor cell maintenanceISSbiological_process
GO:0045776Negative regulation of blood pressureIEAbiological_process
GO:0046907Intracellular transportISSbiological_process
GO:0048854Brain morphogenesisISSbiological_process
GO:0050910Detection of mechanical stimulus involved in sensory perception of soundISSbiological_process
GO:0051082Unfolded protein bindingTASmolecular_function
GO:0051131Chaperone-mediated protein complex assemblyIEAbiological_process
GO:0051216Cartilage developmentIEAbiological_process
GO:0051877Pigment granule aggregation in cell centerISSbiological_process
GO:0060027Convergent extension involved in gastrulationISSbiological_process
GO:0060271Cilium morphogenesisISSbiological_process
GO:0060296Regulation of cilium beat frequency involved in ciliary motilityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.35412724440.43920680830.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.8176692440
GSE13712_SHEARDown-0.3237177854
GSE13712_STATICUp0.0148516874
GSE19018Down-0.3402439399
GSE19899_A1Up0.0654492429
GSE19899_A2Up0.1804808783
PubMed_21979375_A1Up0.0755398300
PubMed_21979375_A2Up0.3917243054
GSE35957Down-0.2507140778
GSE36640Down-0.0471292395
GSE54402Up0.2590661267
GSE9593Down-0.0528101025
GSE43922Up0.2369355543
GSE24585Down-0.2717368615
GSE37065Up0.0415720566
GSE28863_A1Up0.0302768430
GSE28863_A2Down-0.1224184362
GSE28863_A3Down-0.2835227530
GSE28863_A4Down-0.0422152498
GSE48662Up0.0193581854

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.