HCSGD entry for MED25
1. General information
| Official gene symbol | MED25 |
|---|---|
| Entrez ID | 81857 |
| Gene full name | mediator complex subunit 25 |
| Other gene symbols | ACID1 ARC92 CMT2B2 P78 PTOV2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0035563 | Positive regulation of chromatin binding | IMP | biological_process |
| GO:0042974 | Retinoic acid receptor binding | IPI | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046965 | Retinoid X receptor binding | IPI | molecular_function |
| GO:0048147 | Negative regulation of fibroblast proliferation | IMP | biological_process |
| GO:0071158 | Positive regulation of cell cycle arrest | IMP | biological_process |
| GO:2001178 | Positive regulation of mediator complex assembly | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4347626610 | 0.8393570381 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0228707741 |
| GSE13712_SHEAR | Up | 0.0212158940 |
| GSE13712_STATIC | Up | 0.0455942825 |
| GSE19018 | Up | 0.1594680171 |
| GSE19899_A1 | Down | -0.1113216361 |
| GSE19899_A2 | Up | 0.1924824596 |
| PubMed_21979375_A1 | Down | -0.5310767695 |
| PubMed_21979375_A2 | Up | 0.1153728981 |
| GSE35957 | Down | -0.0542124699 |
| GSE36640 | Up | 0.0210251012 |
| GSE54402 | Down | -0.0873430325 |
| GSE9593 | Down | -0.0043565964 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.0674390159 |
| GSE28863_A2 | Up | 0.0799293299 |
| GSE28863_A3 | Up | 0.4598820580 |
| GSE28863_A4 | Up | 0.0466094318 |
| GSE48662 | Up | 0.0836408240 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-3p | MIMAT0004494 | MIRT038966 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT043009 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052170 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
