HCSGD entry for TMX1
1. General information
| Official gene symbol | TMX1 |
|---|---|
| Entrez ID | 81542 |
| Gene full name | thioredoxin-related transmembrane protein 1 |
| Other gene symbols | PDIA11 TMX TXNDC TXNDC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0006260 | DNA replication | NAS | biological_process |
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | biological_process |
| GO:0006950 | Response to stress | NAS | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0008283 | Cell proliferation | NAS | biological_process |
| GO:0015036 | Disulfide oxidoreductase activity | IDA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030612 | Arsenate reductase (thioredoxin) activity | NAS | molecular_function |
| GO:0045321 | Leukocyte activation | NAS | biological_process |
| GO:0045454 | Cell redox homeostasis | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0045927 | Positive regulation of growth | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0458227157 | 0.7308325823 | 0.4743768475 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0898347711 |
| GSE13712_SHEAR | Up | 0.3631850706 |
| GSE13712_STATIC | Up | 0.4010004599 |
| GSE19018 | Up | 0.0702037717 |
| GSE19899_A1 | Up | 0.6728795700 |
| GSE19899_A2 | Down | -0.1234670549 |
| PubMed_21979375_A1 | Up | 0.5710545440 |
| PubMed_21979375_A2 | Down | -0.0217383333 |
| GSE35957 | Down | -0.5313339178 |
| GSE36640 | Down | -0.0532601283 |
| GSE54402 | Up | 0.0697068657 |
| GSE9593 | Down | -0.0389535634 |
| GSE43922 | Up | 0.3458122239 |
| GSE24585 | Up | 0.1037456734 |
| GSE37065 | Up | 0.3829183721 |
| GSE28863_A1 | Up | 0.3844018801 |
| GSE28863_A2 | Up | 0.6245296004 |
| GSE28863_A3 | Down | -0.7427462431 |
| GSE28863_A4 | Up | 0.2143547469 |
| GSE48662 | Down | -0.1147249468 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT005279 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25526565 | Thioredoxin domain-containing 5 (TXNDC5) is a member of the protein disulfide isomerase family, acting as a chaperone of endoplasmic reticulum under not fully characterized conditions As a result, TXNDC5 interacts with many cell proteins, contributing to their proper folding and correct formation of disulfide bonds through its thioredoxin domains |
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