HCSGD entry for GAN
1. General information
| Official gene symbol | GAN |
|---|---|
| Entrez ID | 8139 |
| Gene full name | gigaxonin |
| Other gene symbols | GAN1 KLHL16 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0016567 | Protein ubiquitination | IDA IEA | biological_process |
| GO:0031463 | Cul3-RING ubiquitin ligase complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0075874815 | 0.9174579233 | 0.2270156818 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0438099688 |
| GSE13712_SHEAR | Up | 0.2593974113 |
| GSE13712_STATIC | Up | 0.2152797421 |
| GSE19018 | Down | -0.1159377674 |
| GSE19899_A1 | Up | 0.7039495175 |
| GSE19899_A2 | Up | 1.2426803621 |
| PubMed_21979375_A1 | Up | 2.6266456868 |
| PubMed_21979375_A2 | Up | 1.3456562127 |
| GSE35957 | Down | -0.0211495557 |
| GSE36640 | Up | 0.2370479302 |
| GSE54402 | Up | 0.4137519478 |
| GSE9593 | Up | 0.1271383529 |
| GSE43922 | Up | 0.7202386373 |
| GSE24585 | Down | -0.3261508421 |
| GSE37065 | Down | -0.3957740321 |
| GSE28863_A1 | Up | 0.3373910419 |
| GSE28863_A2 | Up | 0.3060132733 |
| GSE28863_A3 | Down | -0.3869671924 |
| GSE28863_A4 | Down | -0.0444208677 |
| GSE48662 | Up | 0.5246233115 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25331947 | LCMS proteomic analysis of LAP-TAP-purified proteins from HeLa cells containing a tetracycline-inducible GFP-S peptide-NFkappaB expression system identified gigaxonin, an ubiquitin E3 ligase adaptor, as an NFkappaB-interacting protein |
| 25331947 | Furthermore, we have observed increased NFkappaB ubiquitination with cisplatin treatment that is abolished in the absence of p16 and gigaxonin expression |
| 25331947 | These results clearly demonstrate that nuclear p16 and gigaxonin play an important role in chemosensitivity of head and neck cancers through ubiquitination of NFkappaB |
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