HCSGD entry for TCL1A
1. General information
| Official gene symbol | TCL1A |
|---|---|
| Entrez ID | 8115 |
| Gene full name | T-cell leukemia/lymphoma 1A |
| Other gene symbols | TCL1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005938 | Cell cortex | IEA | cellular_component |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0019827 | Stem cell maintenance | IEA | biological_process |
| GO:0045120 | Pronucleus | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9508532123 | 0.5332739903 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0591225635 |
| GSE13712_SHEAR | Down | -0.1277627631 |
| GSE13712_STATIC | Down | -0.0250842983 |
| GSE19018 | Up | 0.0306358644 |
| GSE19899_A1 | Down | -0.0119732831 |
| GSE19899_A2 | Down | -0.1053752512 |
| PubMed_21979375_A1 | Down | -0.0447659515 |
| PubMed_21979375_A2 | Down | -0.0850805719 |
| GSE35957 | Up | 0.1271816895 |
| GSE36640 | Up | 0.0491559247 |
| GSE54402 | Up | 0.0342162509 |
| GSE9593 | Down | -0.0433290183 |
| GSE43922 | Up | 0.0174068387 |
| GSE24585 | Down | -0.0157939883 |
| GSE37065 | Down | -0.0787706427 |
| GSE28863_A1 | Down | -0.1165685642 |
| GSE28863_A2 | Down | -0.1630163129 |
| GSE28863_A3 | Up | 0.2059441772 |
| GSE28863_A4 | Down | -0.0789088440 |
| GSE48662 | Down | -0.0065511366 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29b-3p | MIMAT0000100 | MIRT004510 | Luciferase reporter assay | Functional MTI | 17707831 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT004510 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 17178851 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT005106 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 17178851 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-29b-3p | MIMAT0000100 | 1 | hsa-miR-29b | {Western blot} | {overexpression by mature miRNA transfection} | 17178851 | |
| hsa-miR-181b-5p | MIMAT0000257 | 1 | hsa-miR-181b | {Western blot} | {overexpression by mature miRNA transfection} | 17178851 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11297767 | Telomeric associations and chromosome instability in ataxia telangiectasia T cells characterized by TCL1 expression |
| 11297767 | Malignancy develops years later, after additional chromosomal changes resulting from the genomic instability consequent to ATM disruption and to the activation of the TCL1 oncogene |
| 11297767 | Here we report the results of a cytogenetic follow-up of an AT patient (AT94-1), still without signs of hematological abnormalities, bearing a T-lymphocyte clone characterized by the t(14;14)(q11;q32) rearrangement and having TCL1 expression |
| 11297767 | We demonstrated that in clonal cells TCL1 expression correlates with increasing genomic instability and in time this mainly induces chromosomal rearrangements and telomeric associations (tas) |
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