HCSGD entry for CALR

1. General information

Official gene symbolCALR
Entrez ID811
Gene full namecalreticulin
Other gene symbolsCRT RO SSA cC1qR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001669Acrosomal vesicleIEAcellular_component
GO:0001849Complement component C1q bindingTASmolecular_function
GO:0001948Glycoprotein bindingIEAmolecular_function
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0002502Peptide antigen assembly with MHC class I protein complexISSbiological_process
GO:0003677DNA bindingNASmolecular_function
GO:0003729MRNA bindingIDAmolecular_function
GO:0005178Integrin bindingIPImolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005509Calcium ion bindingIEA ISS TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005622IntracellularTAScellular_component
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005783Endoplasmic reticulumIDA IEA TAScellular_component
GO:0005788Endoplasmic reticulum lumenIDA TAScellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005844PolysomeISScellular_component
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0006457Protein foldingIEA TASbiological_process
GO:0006611Protein export from nucleusIDAbiological_process
GO:0006874Cellular calcium ion homeostasisTASbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0007050Cell cycle arrestIGIbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008270Zinc ion bindingTASmolecular_function
GO:0008284Positive regulation of cell proliferationIGIbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0009986Cell surfaceTAScellular_component
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0017148Negative regulation of translationISS TASbiological_process
GO:0018279Protein N-linked glycosylation via asparagineTASbiological_process
GO:0022417Protein maturation by protein foldingTASbiological_process
GO:0030246Carbohydrate bindingTASmolecular_function
GO:0030866Cortical actin cytoskeleton organizationIEAbiological_process
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032355Response to estradiolIEAbiological_process
GO:0033018Sarcoplasmic reticulum lumenIEAcellular_component
GO:0033144Negative regulation of intracellular steroid hormone receptor signaling pathwayIDAbiological_process
GO:0033574Response to testosteroneIEAbiological_process
GO:0034504Protein localization to nucleusIDAbiological_process
GO:0040020Regulation of meiosisIEAbiological_process
GO:0042277Peptide bindingIEAmolecular_function
GO:0042493Response to drugIEAbiological_process
GO:0042562Hormone bindingIEAmolecular_function
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042824MHC class I peptide loading complexISScellular_component
GO:0042921Glucocorticoid receptor signaling pathwayTASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043687Post-translational protein modificationTASbiological_process
GO:0044183Protein binding involved in protein foldingTASmolecular_function
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045665Negative regulation of neuron differentiationIDAbiological_process
GO:0045740Positive regulation of DNA replicationIGIbiological_process
GO:0045787Positive regulation of cell cycleIGIbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0048387Negative regulation of retinoic acid receptor signaling pathwayIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050681Androgen receptor bindingIDAmolecular_function
GO:0050766Positive regulation of phagocytosisISSbiological_process
GO:0050821Protein stabilizationISS TASbiological_process
GO:0051082Unfolded protein bindingIEA TASmolecular_function
GO:0051087Chaperone bindingTASmolecular_function
GO:0051208Sequestering of calcium ionTASbiological_process
GO:0055007Cardiac muscle cell differentiationIEAbiological_process
GO:0061077Chaperone-mediated protein foldingIEAbiological_process
GO:0071285Cellular response to lithium ionIEAbiological_process
GO:0071556Integral component of lumenal side of endoplasmic reticulum membraneTAScellular_component
GO:0071682Endocytic vesicle lumenTAScellular_component
GO:0090398Cellular senescenceIGIbiological_process
GO:1900026Positive regulation of substrate adhesion-dependent cell spreadingIMPbiological_process
GO:2000510Positive regulation of dendritic cell chemotaxisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94288276660.03372165950.99999024730.3469850665

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2945264398
GSE13712_SHEARDown-0.1810916340
GSE13712_STATICDown-0.0864236998
GSE19018Up0.2698260586
GSE19899_A1Down-0.6746771349
GSE19899_A2Down-0.0692385949
PubMed_21979375_A1Down-1.3233896520
PubMed_21979375_A2Down-1.1745312947
GSE35957Up0.2998701507
GSE36640Down-0.2317532662
GSE54402Down-0.1636342878
GSE9593Down-0.2419158480
GSE43922Down-0.1712139430
GSE24585Up0.0221650144
GSE37065Down-0.0290616400
GSE28863_A1Up0.0406178768
GSE28863_A2Up0.0915181783
GSE28863_A3Down-0.3911835084
GSE28863_A4Up0.0835947044
GSE48662Down-0.2883955826

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TenecteplaseDB00031 BTD00019 | BIOD00019
MelatoninDB01065 APRD00742 | DB08189

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022337MicroarrayFunctional MTI (Weak)18668037
hsa-miR-122-5pMIMAT0000421MIRT023227ProteomicsFunctional MTI (Weak)21750653
hsa-miR-1MIMAT0000416MIRT023576MicroarrayFunctional MTI (Weak)18668037
hsa-miR-16-5pMIMAT0000069MIRT031457ProteomicsFunctional MTI (Weak)18668040
hsa-miR-423-3pMIMAT0001340MIRT042481CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044537CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045548CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25378661We have previously reported that exchange protein directly activated by cAMP 2 (EPAC2, RAPGEF4), another cAMP mediator, is involved in the differentiation of endometrial stromal cells through the regulation of the expression of calreticulin (CALR)
25378661EPAC2 knockdown suppressed the expression of CALR protein and mRNA in EM1 cells
25378661In addition, knockdown of EPAC2 or CALR increased senescence-associated beta galactosidase activity and expression of p21 but decreased expression of p53
25378661These findings indicate that expression of CALR regulated by EPAC2 in endometrial glandular epithelial cells is critical for the expression of LIF and PTGS2-mediated production of PGE2 through cAMP signaling
25378661Furthermore, EPAC2 and CALR could play a role in the maintenance of gland function
24169561The role of exchange protein directly activated by cyclic AMP 2-mediated calreticulin expression in the decidualization of human endometrial stromal cells
14726956Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate
14726956Two RNA-binding proteins, CUGBP1 and calreticulin (CRT), interact with the same nucleotide sequences within the 5' region of p21 mRNA, but have opposite effects on the translation of p21 mRNA
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