HCSGD entry for HMGA2
1. General information
| Official gene symbol | HMGA2 |
|---|---|
| Entrez ID | 8091 |
| Gene full name | high mobility group AT-hook 2 |
| Other gene symbols | BABL HMGI-C HMGIC LIPO STQTL9 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0000228 | Nuclear chromosome | ISS | cellular_component |
| GO:0000785 | Chromatin | IEA | cellular_component |
| GO:0000975 | Regulatory region DNA binding | IDA | molecular_function |
| GO:0000988 | Protein binding transcription factor activity | IDA | molecular_function |
| GO:0001047 | Core promoter binding | IDA | molecular_function |
| GO:0001077 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | IDA | molecular_function |
| GO:0001078 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | IDA | molecular_function |
| GO:0001837 | Epithelial to mesenchymal transition | IMP | biological_process |
| GO:0002062 | Chondrocyte differentiation | IDA | biological_process |
| GO:0003131 | Mesodermal-endodermal cell signaling | IMP | biological_process |
| GO:0003677 | DNA binding | IEA NAS | molecular_function |
| GO:0003680 | AT DNA binding | IDA IMP | molecular_function |
| GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity | IDA | molecular_function |
| GO:0004677 | DNA-dependent protein kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0006284 | Base-excision repair | IDA | biological_process |
| GO:0006325 | Chromatin organization | TAS | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA IMP | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007095 | Mitotic G2 DNA damage checkpoint | IDA | biological_process |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0008301 | DNA binding, bending | IDA IMP | molecular_function |
| GO:0008584 | Male gonad development | IEA | biological_process |
| GO:0009615 | Response to virus | IEP | biological_process |
| GO:0010564 | Regulation of cell cycle process | IDA | biological_process |
| GO:0010628 | Positive regulation of gene expression | IDA | biological_process |
| GO:0019899 | Enzyme binding | IEA | molecular_function |
| GO:0021846 | Cell proliferation in forebrain | IEA | biological_process |
| GO:0021983 | Pituitary gland development | IEA | biological_process |
| GO:0030261 | Chromosome condensation | IEA | biological_process |
| GO:0030325 | Adrenal gland development | IEA | biological_process |
| GO:0031052 | Chromosome breakage | IDA | biological_process |
| GO:0031492 | Nucleosomal DNA binding | IDA | molecular_function |
| GO:0031507 | Heterochromatin assembly | IDA | biological_process |
| GO:0032993 | Protein-DNA complex | IDA | cellular_component |
| GO:0033144 | Negative regulation of intracellular steroid hormone receptor signaling pathway | IEA | biological_process |
| GO:0035019 | Somatic stem cell maintenance | IEA | biological_process |
| GO:0035497 | CAMP response element binding | IDA | molecular_function |
| GO:0035500 | MH2 domain binding | IDA | molecular_function |
| GO:0035501 | MH1 domain binding | IDA | molecular_function |
| GO:0035978 | Histone H2A-S139 phosphorylation | IDA | biological_process |
| GO:0035985 | Senescence-associated heterochromatin focus | IDA | cellular_component |
| GO:0035986 | Senescence-associated heterochromatin focus assembly | IDA | biological_process |
| GO:0035987 | Endodermal cell differentiation | IMP | biological_process |
| GO:0035988 | Chondrocyte proliferation | IDA | biological_process |
| GO:0040018 | Positive regulation of multicellular organism growth | IEA | biological_process |
| GO:0042769 | DNA damage response, detection of DNA damage | IDA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IDA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
| GO:0043392 | Negative regulation of DNA binding | IDA | biological_process |
| GO:0043922 | Negative regulation by host of viral transcription | IDA | biological_process |
| GO:0045444 | Fat cell differentiation | IMP | biological_process |
| GO:0045869 | Negative regulation of single stranded viral RNA replication via double stranded DNA intermediate | IDA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA IMP | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA IMP | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046332 | SMAD binding | IPI | molecular_function |
| GO:0046426 | Negative regulation of JAK-STAT cascade | IEA | biological_process |
| GO:0048333 | Mesodermal cell differentiation | IMP | biological_process |
| GO:0048712 | Negative regulation of astrocyte differentiation | IEA | biological_process |
| GO:0048762 | Mesenchymal cell differentiation | IMP | biological_process |
| GO:0048863 | Stem cell differentiation | IEP | biological_process |
| GO:0051091 | Positive regulation of sequence-specific DNA binding transcription factor activity | IEA | biological_process |
| GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity | IDA | molecular_function |
| GO:0060123 | Regulation of growth hormone secretion | IEA | biological_process |
| GO:0060613 | Fat pad development | IEA | biological_process |
| GO:0070742 | C2H2 zinc finger domain binding | IMP | molecular_function |
| GO:0071141 | SMAD protein complex | IDA | cellular_component |
| GO:0071158 | Positive regulation of cell cycle arrest | IDA | biological_process |
| GO:0090402 | Oncogene-induced cell senescence | IDA | biological_process |
| GO:2000036 | Regulation of stem cell maintenance | IMP TAS | biological_process |
| GO:2000648 | Positive regulation of stem cell proliferation | IDA IMP | biological_process |
| GO:2000679 | Positive regulation of transcription regulatory region DNA binding | IDA | biological_process |
| GO:2000685 | Positive regulation of cellular response to X-ray | IDA | biological_process |
| GO:2000774 | Positive regulation of cellular senescence | IMP | biological_process |
| GO:2001022 | Positive regulation of response to DNA damage stimulus | IDA | biological_process |
| GO:2001033 | Negative regulation of double-strand break repair via nonhomologous end joining | IDA | biological_process |
| GO:2001038 | Regulation of cellular response to drug | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0197778466 | 0.8587696592 | 0.3412990190 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5217231410 |
| GSE13712_SHEAR | Up | 0.1740916917 |
| GSE13712_STATIC | Up | 0.3572161285 |
| GSE19018 | Up | 0.1698180230 |
| GSE19899_A1 | Up | 0.3591288031 |
| GSE19899_A2 | Up | 1.4586561518 |
| PubMed_21979375_A1 | Down | -0.0556555315 |
| PubMed_21979375_A2 | Up | 0.3777266509 |
| GSE35957 | Down | -0.0386928238 |
| GSE36640 | Down | -0.8531382734 |
| GSE54402 | Up | 0.9307005274 |
| GSE9593 | Up | 0.1530563596 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.3201401700 |
| GSE28863_A2 | Up | 0.3577376856 |
| GSE28863_A3 | Down | -0.3020132919 |
| GSE28863_A4 | Up | 0.5410354716 |
| GSE48662 | Down | -0.3530659141 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26a-5p | MIMAT0000082 | MIRT000109 | Luciferase reporter assay | Functional MTI | 17563749 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT000348 | Luciferase reporter assay | Functional MTI | 17563749 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT000748 | Microarray | Functional MTI (Weak) | 19461653 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT002005 | qRT-PCR//ChIP//Luciferase reporter assay | Functional MTI | 20395557 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT002005 | Western blot | Functional MTI | 17957144 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT002081 | Luciferase reporter assay//qRT-PCR | Functional MTI | 17437991 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT002082 | Luciferase reporter assay//qRT-PCR | Functional MTI | 17437991 |
| hsa-let-7g-5p | MIMAT0000414 | MIRT002097 | Western blot//Reporter assay | Functional MTI | 18413726 |
| hsa-let-7g-5p | MIMAT0000414 | MIRT002097 | Luciferase reporter assay | Functional MTI | 17600087 |
| hsa-let-7g-5p | MIMAT0000414 | MIRT002097 | Luciferase reporter assay | Functional MTI | 18308936 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT002322 | qRT-PCR//Western blot//Luciferase reporter assay | Functional MTI | 17600087 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT002322 | Microarray//Northern blot//qRT-PCR//Western blot | Functional MTI | 17243163 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT002322 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18403645 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT002322 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT002323 | qRT-PCR//Western blot//Luciferase reporter assay | Functional MTI | 17600087 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT002323 | Luciferase reporter assay | Functional MTI | 18083101 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT002323 | Luciferase reporter assay | Functional MTI | 17322030 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT002323 | Luciferase reporter assay | Functional MTI | 18413822 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT002323 | Luciferase reporter assay//Western blot//qRT-PCR | Functional MTI | 19179606 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT002323 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT002999 | Northern blot//qRT-PCR//Western blot;Other | Functional MTI | 17222355 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT002999 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-370-3p | MIMAT0000722 | MIRT003713 | Luciferase reporter assay | Non-Functional MTI | 19179606 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT004702 | Flow//Immunoblot//Microarray//qRT-PCR | Functional MTI (Weak) | 19688090 |
| hsa-miR-760 | MIMAT0004957 | MIRT036768 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT051403 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | 1 | hsa-let-7b | {Western blot}{Western blot} | {overexpression by siRNA transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 17437991 | |
| hsa-let-7b-5p | MIMAT0000063 | 4 | hsa-let-7b | {Western blot}{Western blot} | {overexpression by siRNA transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 17437991 | |
| hsa-let-7b-5p | MIMAT0000063 | 5 | hsa-let-7b | {Western blot}{Western blot} | {overexpression by siRNA transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 17437991 | |
| hsa-let-7b-5p | MIMAT0000063 | 2 | hsa-let-7b | {Western blot}{Western blot} | {overexpression by siRNA transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 17437991 | |
| hsa-let-7b-5p | MIMAT0000063 | 3 | hsa-let-7b | {Western blot}{Western blot} | {overexpression by siRNA transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 17437991 | |
| hsa-let-7b-5p | MIMAT0000063 | 6 | hsa-let-7b | {Western blot}{Western blot} | {overexpression by siRNA transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 17437991 | |
| hsa-let-7e-5p | MIMAT0000066 | 3 | hsa-let-7e | {Western blot}{Western blot} | {overexpression by siRNA transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 17437991 | |
| hsa-let-7e-5p | MIMAT0000066 | 6 | hsa-let-7e | {Western blot}{Western blot} | {overexpression by siRNA transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 17437991 | |
| hsa-let-7e-5p | MIMAT0000066 | 4 | hsa-let-7e | {Western blot}{Western blot} | {overexpression by siRNA transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 17437991 | |
| hsa-let-7e-5p | MIMAT0000066 | 2 | hsa-let-7e | {Western blot}{Western blot} | {overexpression by siRNA transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 17437991 | |
| hsa-let-7e-5p | MIMAT0000066 | 1 | hsa-let-7e | {Western blot}{Western blot} | {overexpression by siRNA transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 17437991 | |
| hsa-let-7e-5p | MIMAT0000066 | 5 | hsa-let-7e | {Western blot}{Western blot} | {overexpression by siRNA transfection}{underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 17437991 | |
| hsa-let-7a-5p | MIMAT0000062 | 2 | hsa-let-7a | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17600087 | |
| hsa-let-7a-5p | MIMAT0000062 | 3 | hsa-let-7a | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17600087 | |
| hsa-let-7a-5p | MIMAT0000062 | 5 | hsa-let-7a | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17600087 | |
| hsa-let-7a-5p | MIMAT0000062 | 7 | hsa-let-7a | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17600087 | |
| hsa-let-7a-5p | MIMAT0000062 | 1 | hsa-let-7a | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17600087 | |
| hsa-let-7a-5p | MIMAT0000062 | 4 | hsa-let-7a | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17600087 | |
| hsa-let-7a-5p | MIMAT0000062 | 6 | hsa-let-7a | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17600087 | |
| hsa-let-7g-5p | MIMAT0000414 | 1 | hsa-let-7g | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17600087 | |
| hsa-let-7g-5p | MIMAT0000414 | 3 | hsa-let-7g | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17600087 | |
| hsa-let-7g-5p | MIMAT0000414 | 5 | hsa-let-7g | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17600087 | |
| hsa-let-7g-5p | MIMAT0000414 | 4 | hsa-let-7g | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17600087 | |
| hsa-let-7g-5p | MIMAT0000414 | 7 | hsa-let-7g | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17600087 | |
| hsa-let-7g-5p | MIMAT0000414 | 6 | hsa-let-7g | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17600087 | |
| hsa-let-7g-5p | MIMAT0000414 | 2 | hsa-let-7g | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17600087 | |
| hsa-miR-98-5p | MIMAT0000096 | 5 | hsa-miR-98 | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17222355 | |
| hsa-miR-98-5p | MIMAT0000096 | 2 | hsa-miR-98 | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17222355 | |
| hsa-miR-98-5p | MIMAT0000096 | 4 | hsa-miR-98 | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17222355 | |
| hsa-miR-98-5p | MIMAT0000096 | 6 | hsa-miR-98 | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17222355 | |
| hsa-miR-98-5p | MIMAT0000096 | 7 | hsa-miR-98 | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17222355 | |
| hsa-miR-98-5p | MIMAT0000096 | 3 | hsa-miR-98 | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17222355 | |
| hsa-miR-98-5p | MIMAT0000096 | 1 | hsa-miR-98 | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by anti-miRNA oligonucleotides} | 17222355 | |
| hsa-miR-204-5p | MIMAT0000265 | NA | hsa-miR-204 | 20369013 | |||
| hsa-miR-185-5p | MIMAT0000455 | NA | hsa-miR-185 | 19688090 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 15 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24476133 | Moreover, induction of SIPS was mediated by HMGA2, which colocalized to senescence-associated heterochromatin foci |
| 23969248 | Rb protein is essential to the senescence-associated heterochromatic foci formation induced by HMGA2 in primary WI38 cells |
| 23969248 | Surprisingly, although high mobility group A2 protein (HMGA2) can promote tumorigenesis and inhibit Rb function in tumor cells, high-level expression of HMGA2 is sufficient to induce SAHF formation in primary cells |
| 23969248 | In this study, we established the cellular senescence and SAHF assembly WI38 cell model by ectopic expression of HMGA2, in which typical senescent markers were seen, including notable upregulation of p53, p21 and p16, and elevated SA-beta-galactosidase staining together with downregulation of E2F target genes |
| 23969248 | We then showed that the Rb pathway inhibitor E7 protein was able to partly abolish the ability of SAHF formation after HMGA2 expression in WI38 cells, indicating that Rb is a crucial factor for HMGA2-induced SAHF formation |
| 23969248 | However, Rb depletion did not completely rescue the cell growth arrest induced by HMGA2, suggesting that Rb is not an exclusive pathway for HMGA2-induced senescence in WI38 cells |
| 23881689 | HMGA2 expression in white adipose tissue linking cellular senescence with diabetes |
| 23881689 | The molecular mechanism of the gain of adipose tissue is linked with the expression of high mobility group protein AT-hook 2 (HMGA2), and recent studies revealed an association with a SNP near HMGA2 |
| 23881689 | We found a significant higher HMGA2 expression in obese individuals than in non-obese patients |
| 23881689 | Furthermore, the HMGA2 expression in white adipose tissue in patient with type 2 diabetes was significantly higher than in nondiabetic patients |
| 23881689 | There is an association between the DNA-binding nonhistone protein HMGA2 and the risk of developing T2D that remains mechanistically unexplained so far |
| 23276696 | HMGA2 regulates the in vitro aging and proliferation of human umbilical cord blood-derived stromal cells through the mTOR/p70S6K signaling pathway |
| 23276696 | The human high-mobility group protein A2 (HMGA2) protein is an architectural transcription factor that transforms chromatin structure by binding to DNA |
| 23276696 | Recently, it has been reported that HMGA2 is highly expressed in fetal neural stem cells and has the capacity to promote stemness |
| 23276696 | In the present study, we evaluated the direct effects of HMGA2 on the cellular aging and proliferation of hUCBSCs and investigated potential regulatory mechanisms responsible for the corresponding functions |
| 23276696 | We found that the overexpression of HMGA2 enhanced proliferation and reduced or even reversed the in vitro aging process of hUCBSCs |
| 23276696 | Furthermore, HMGA2 inhibition compromised cell proliferation and adipogenic differentiation in early-stage hUCBSCs |
| 23276696 | These results provide novel insights into the mechanism by which HMGA2 regulates the in vitro aging and proliferation of hUCBSCs |
| 23072816 | We identified 2 microRNAs, microRNA-10A* (miR-10A*), and miR-21, and their common target gene Hmga2 as critical regulators for EPC senescence |
| 23072816 | Overexpression of miR-10A* and miR-21 in young EPCs suppressed Hmga2 expression, caused EPC senescence, as evidenced by senescence-associated beta-galactosidase upregulation, decreased self-renewal potential, increased p16(Ink4a)/p19(Arf) expression, and resulted in impaired EPC angiogenesis in vitro and in vivo, resembling EPCs derived from aged mice |
| 23072816 | In contrast, suppression of miR-10A* and miR-21 in aged EPCs increased Hmga2 expression, rejuvenated EPCs, resulting in decreased senescence-associated beta-galactosidase expression, increased self-renewal potential, decreased p16(Ink4a)/p19(Arf) expression, and improved EPC angiogenesis in vitro and in vivo |
| 23072816 | Importantly, these phenotypic changes were rescued by miRNA-resistant Hmga2 cDNA overexpression |
| 23072816 | CONCLUSIONS: miR-10A* and miR-21 regulate EPC senescence via suppressing Hmga2 expression and modulation of microRNAs may represent a potential therapeutic intervention in improving EPC-mediated angiogenesis and vascular repair |
| 21515304 | Increase in senescent associated markers such as p21, HMGA2 and PAI-1 was more prominent in DPV treated cells compared to similar dose of H(2)O(2) |
| 21498692 | HMGA2 and p14Arf: major roles in cellular senescence of fibroids and therapeutic implications |
| 21498692 | RESULTS: In fibroid cells, expression of HMGA2 decreased with passaging while that of p14(Arf) increased |
| 21498692 | CONCLUSION: p14(Arf) and HMGA2 seem to play a pivotal role in controlling the growth of fibroid cells |
| 21456046 | HMGA2 is a major regulator of benign tumorigenesis from mesenchyme-derived tissues and stem-cell self-renewal |
| 21456046 | To repress the oncogenic activity of HMGA2, the lin-28-let-7 axis is thought to increasingly repress the expression of HMGA2 with age |
| 21456046 | The expression of both genes was inversely correlated during senescence in vitro but contrary to the expectations in adipose tissue derived stem cells (ADSCs) stimulation of HMGA2 by FGF1 increased the expression of p14(Arf) |
| 21456046 | Based on the assumption that in ADSCs p14(Arf) is repressing HMGA2, siRNA silencing of p14(Arf) was performed resulting in a significant upregulation of HMGA2 |
| 21456046 | To see if p14(Arf) can repress HMGA2 by a TP53-dependent mechanism, nutlin-3, a known MDM2 antagonist, was used which not only increased the activity of the senescence, associated markers p21 and beta-galactosidase, but also decreased the expression of HMGA2, suggesting that p14(Arf) indeed influences HMGA2 by a p53-dependent mechanism because nutlin-3 stabilizes p53 |
| 21456046 | Accordingly, the HMGA2 response triggered by serum was reduced by treatment of ADSCs with nutlin-3 |
| 21456046 | As to the interaction between HMGA2 and p14(Arf) in benign tumorigenesis, we propose a model where akin to MSC self-renewal during tissue repair the simultaneous increase of p14(Arf) with HMGA2 ensures genomic stability, whereas in turn p14(Arf) can repress HMGA2 via TP53 |
| 20652617 | Here, we observed that the cellular senescence of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs) caused by inhibition of histone deacetylase (HDAC) activity leads to down-regulation of high mobility group A2 (HMGA2) and, on the contrary, to up-regulation of p16(INK)(4)(A), p21(CIP)(1)(/WAF)(1) and p27(KIP)(1) |
| 20652617 | We confirmed that miR-23a, miR-26a and miR-30a inhibit HMGA2 to accelerate the progress of senescence |
| 20652617 | These findings suggest that HDACs may play important roles in cellular senescence by regulating the expression of miRNAs that target HMGA2 through histone modification |
| 19217096 | MAIN OUTCOME MEASURE(S): Senescence measured by percentage of SA-beta-Gal-positive cells; levels of let-7 microRNAs measured by RT-PCR and MISH; expression of p16(INK4a), Ki-67, HMGA1, and HMGA2 scaled by immunoreactivity |
| 19070572 | HMGA2, microRNAs, and stem cell aging |
| 18983959 | Ink4a/Arf regulation by let-7b and Hmga2: a genetic pathway governing stem cell aging |
| 18983959 | In a recent issue of Cell, Nishino and colleagues (2008) show that Hmga2 maintains neural stem cell (NSC) function in young mice through repression of the Ink4a/Arf locus; in contrast, during aging, elevated let-7b blocks Hmga2 and contributes to declining NSC function |
| 18505920 | HMGA2 participates in transformation in human lung cancer |
| 18505920 | Although previous studies have established a prominent role for HMGA1 (formerly HMG-I/Y) in aggressive human cancers, the role of HMGA2 (formerly HMGI-C) in malignant transformation has not been clearly defined |
| 18505920 | The HMGA gene family includes HMGA1, which encodes the HMGA1a and HMGA1b protein isoforms, and HMGA2, which encodes HMGA2 |
| 18505920 | HMGA1 proteins also appear to participate in cell cycle regulation and malignant transformation, whereas HMGA2 has been implicated primarily in the pathogenesis of benign, mesenchymal tumors |
| 18505920 | Here, we show that overexpression of HMGA2 leads to a transformed phenotype in cultured lung cells derived from normal tissue |
| 18505920 | Conversely, inhibiting HMGA2 expression blocks the transformed phenotype in metastatic human non-small cell lung cancer cells |
| 18505920 | Moreover, we show that HMGA2 mRNA and protein are overexpressed in primary human lung cancers compared with normal tissue or indolent tumors |
| 18505920 | In addition, there is a statistically significant correlation between HMGA2 protein staining by immunohistochemical analysis and tumor grade (P < 0 |
| 18505920 | Our results indicate that HMGA2 is an oncogene important in the pathogenesis of human lung cancer |
| 18505920 | Although additional studies with animal models are needed, these findings suggest that targeting HMGA2 could be therapeutically beneficial in lung cancer and other cancers characterized by increased HMGA2 expression |
| 17158953 | However, the simultaneous ectopic expression of hemagglutinin-tagged HMGA2 and N-terminally EGFP-tagged histone H1 leads to significant SAHF formation (P < 0 |
| 16901784 | These antiproliferative activities are canceled by coexpression of the HDM2 and CDK4 oncogenes, which are often coamplified with HMGA2 in human cancers |
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