HCSGD entry for SETD7
1. General information
| Official gene symbol | SETD7 |
|---|---|
| Entrez ID | 80854 |
| Gene full name | SET domain containing (lysine methyltransferase) 7 |
| Other gene symbols | KMT7 SET7 SET7/9 SET9 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002039 | P53 binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0016279 | Protein-lysine N-methyltransferase activity | IDA | molecular_function |
| GO:0016568 | Chromatin modification | NAS | biological_process |
| GO:0018024 | Histone-lysine N-methyltransferase activity | IDA IEA NAS | molecular_function |
| GO:0018026 | Peptidyl-lysine monomethylation | IDA | biological_process |
| GO:0018027 | Peptidyl-lysine dimethylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1363907678 | 0.9435728126 | 0.7450168637 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2620200297 |
| GSE13712_SHEAR | Up | 0.2136275380 |
| GSE13712_STATIC | Down | -0.0712943043 |
| GSE19018 | Up | 0.1514222182 |
| GSE19899_A1 | Up | 0.1807868490 |
| GSE19899_A2 | Up | 0.0522647663 |
| PubMed_21979375_A1 | Up | 0.2944949836 |
| PubMed_21979375_A2 | Up | 0.3355129933 |
| GSE35957 | Up | 0.3994085435 |
| GSE36640 | Up | 0.5402486064 |
| GSE54402 | Up | 0.0447581263 |
| GSE9593 | Up | 0.1600240933 |
| GSE43922 | Up | 0.1878460686 |
| GSE24585 | Down | -0.0388692178 |
| GSE37065 | Down | -0.2448170634 |
| GSE28863_A1 | Down | -0.0351668082 |
| GSE28863_A2 | Down | -0.0337682242 |
| GSE28863_A3 | Up | 0.1312711697 |
| GSE28863_A4 | Down | -0.0768702845 |
| GSE48662 | Down | -0.2028857188 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Compound | Target | Confidence score | Uniprot |
|---|---|---|---|
| CHEMBL1214186 | CHEMBL5523 | 9 | Q8WTS6 |
| CHEMBL1797443 | CHEMBL5523 | 8 | Q8WTS6 |
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| S-Adenosyl-L-Homocysteine | DB01752 | EXPT02842 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-590-3p | MIMAT0004801 | MIRT016229 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-151a-3p | MIMAT0000757 | MIRT019502 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-375 | MIMAT0000728 | MIRT020048 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT022071 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028334 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT028705 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-484 | MIMAT0002174 | MIRT042147 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045305 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047488 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-28-5p | MIMAT0000085 | MIRT050006 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052483 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26168478 | Conversely, the transcription factors Ets1/2 and histone H3K4 methyltransferase MLL1 directly bind to the p16 locus and mediate p16 induction during replicative and premature senescence |
| 25698448 | Here we report that JMJD3, a histone demethylase catalyzing the tri-methylation of H3K27 (H3K27me3), can demethylate the non-histone protein RB at the lysine810 residue (K810), which is a target of the methyltransferase Set7/9 |
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