HCSGD entry for FOSL1

1. General information

Official gene symbolFOSL1
Entrez ID8061
Gene full nameFOS-like antigen 1
Other gene symbolsFRA FRA1 fra-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006935ChemotaxisTASbiological_process
GO:0006968Cellular defense responseTASbiological_process
GO:0007296VitellogenesisIEAbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007612LearningIEAbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009615Response to virusTASbiological_process
GO:0009629Response to gravityIEAbiological_process
GO:0031668Cellular response to extracellular stimulusIEAbiological_process
GO:0032570Response to progesteroneIEAbiological_process
GO:0034097Response to cytokineIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0042734Presynaptic membraneIEAcellular_component
GO:0043005Neuron projectionIEAcellular_component
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0045787Positive regulation of cell cycleIEAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIEAbiological_process
GO:0051412Response to corticosteroneIEAbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0060674Placenta blood vessel developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05658742830.07249432390.51644857840.5072097554

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7393401816
GSE13712_SHEARUp1.4146904232
GSE13712_STATICUp1.2481726757
GSE19018Down-0.1649471088
GSE19899_A1Down-1.4976740158
GSE19899_A2Down-0.7673704523
PubMed_21979375_A1Up0.1660601568
PubMed_21979375_A2Down-0.0820487402
GSE35957Up0.0174760340
GSE36640Down-0.8512270341
GSE54402Up0.4347731056
GSE9593Up0.7062613069
GSE43922Down-0.2121625376
GSE24585Up0.1611080203
GSE37065Up0.1596589971
GSE28863_A1Down-0.2828013373
GSE28863_A2Up0.1937758553
GSE28863_A3Up0.0411953482
GSE28863_A4Down-0.0153619450
GSE48662Down-0.3365695518

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT006546Immunoprecipitaion//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22198213
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19682489Moreover, co-localization of MMP-7 and HB-EGF as well as a concomittant downstream signaling via Fra-1 indicated a possible association between the reduced MMP-7 enzyme activity and an impaired HB-EGF processing, resulting in an enhanced tropoelastin synthesis during senescence of HMEC
7684831Likewise, expression of fra-1, c-jun and junB continued to be high in serum-stimulated senescent cells, while induction of fosB was reduced approximately fivefold
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