HCSGD entry for CD276
1. General information
| Official gene symbol | CD276 |
|---|---|
| Entrez ID | 80381 |
| Gene full name | CD276 molecule |
| Other gene symbols | 4Ig-B7-H3 B7-H3 B7H3 B7RP-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005102 | Receptor binding | IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006955 | Immune response | NAS | biological_process |
| GO:0008283 | Cell proliferation | NAS | biological_process |
| GO:0009897 | External side of plasma membrane | IEA NAS | cellular_component |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0030501 | Positive regulation of bone mineralization | IEA | biological_process |
| GO:0042102 | Positive regulation of T cell proliferation | IDA | biological_process |
| GO:0042110 | T cell activation | IDA | biological_process |
| GO:0042130 | Negative regulation of T cell proliferation | IEA | biological_process |
| GO:0045077 | Negative regulation of interferon-gamma biosynthetic process | IEA | biological_process |
| GO:0045078 | Positive regulation of interferon-gamma biosynthetic process | IDA | biological_process |
| GO:0045085 | Negative regulation of interleukin-2 biosynthetic process | IEA | biological_process |
| GO:0045669 | Positive regulation of osteoblast differentiation | IEA | biological_process |
| GO:0050728 | Negative regulation of inflammatory response | IEA | biological_process |
| GO:0050776 | Regulation of immune response | IEA NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0576969340 | 0.8082149500 | 0.5208685293 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2194474935 |
| GSE13712_SHEAR | Up | 0.0489691017 |
| GSE13712_STATIC | Up | 0.1830522766 |
| GSE19018 | Down | -0.0365093003 |
| GSE19899_A1 | Up | 0.1686756567 |
| GSE19899_A2 | Up | 0.0512431431 |
| PubMed_21979375_A1 | Up | 0.6697759989 |
| PubMed_21979375_A2 | Up | 0.5212922859 |
| GSE35957 | Down | -0.2313131454 |
| GSE36640 | Up | 0.1108695151 |
| GSE54402 | Up | 0.0212767166 |
| GSE9593 | Up | 0.5563662074 |
| GSE43922 | Up | 0.3698978151 |
| GSE24585 | Down | -0.6072197888 |
| GSE37065 | Up | 0.1825300623 |
| GSE28863_A1 | Up | 0.2814164691 |
| GSE28863_A2 | Up | 0.4867553452 |
| GSE28863_A3 | Down | -0.0519953116 |
| GSE28863_A4 | Down | -0.2388670841 |
| GSE48662 | Up | 0.1995048277 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29a-3p | MIMAT0000086 | MIRT003343 | Luciferase reporter assay//Western blot | Functional MTI | 19584290 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018004 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036011 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-421 | MIMAT0003339 | MIRT039444 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049416 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-28-5p | MIMAT0000085 | MIRT050009 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052388 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052669 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-29a-3p | MIMAT0000086 | 1 | hsa-miR-29a | {Western blot} | {overexpression by miRNA mimics tranfection} | 19584290 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18829542 | Moreover, these exosomes were enriched in B7-H3 protein, a recently identified diagnostic marker for prostate cancer, and an abundance of what has recently been termed "exosomal shuttle RNA |
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