HCSGD entry for SHOC2
1. General information
| Official gene symbol | SHOC2 |
|---|---|
| Entrez ID | 8036 |
| Gene full name | soc-2 suppressor of clear homolog (C. elegans) |
| Other gene symbols | SIAA0862 SOC2 SUR8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000164 | Protein phosphatase type 1 complex | IDA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA NAS | cellular_component |
| GO:0007265 | Ras protein signal transduction | NAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | NAS | biological_process |
| GO:0019888 | Protein phosphatase regulator activity | TAS | molecular_function |
| GO:0019903 | Protein phosphatase binding | IDA | molecular_function |
| GO:0046579 | Positive regulation of Ras protein signal transduction | IMP | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9751767448 | 0.0184178679 | 0.9999902473 | 0.2656310685 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1200027886 |
| GSE13712_SHEAR | Down | -0.0259779103 |
| GSE13712_STATIC | Down | -0.0316432748 |
| GSE19018 | Down | -0.0185727304 |
| GSE19899_A1 | Down | -0.7433913756 |
| GSE19899_A2 | Down | -0.5960935284 |
| PubMed_21979375_A1 | Down | -0.1212245289 |
| PubMed_21979375_A2 | Down | -0.4089922247 |
| GSE35957 | Up | 0.1668049041 |
| GSE36640 | Up | 0.1299503291 |
| GSE54402 | Up | 0.0197020039 |
| GSE9593 | Down | -0.0186270946 |
| GSE43922 | Down | -0.3639607381 |
| GSE24585 | Down | -0.0801019662 |
| GSE37065 | Up | 0.0499494002 |
| GSE28863_A1 | Down | -0.3338273981 |
| GSE28863_A2 | Down | -0.3857515192 |
| GSE28863_A3 | Down | -0.8459334907 |
| GSE28863_A4 | Up | 0.1534740134 |
| GSE48662 | Down | -0.6919157582 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001418 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001418 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017593 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027120 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029283 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049230 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
