HCSGD entry for TNKS2
1. General information
| Official gene symbol | TNKS2 |
|---|---|
| Entrez ID | 80351 |
| Gene full name | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 |
| Other gene symbols | ARTD6 PARP-5b PARP-5c PARP5B PARP5C TANK2 TNKL pART6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0000242 | Pericentriolar material | IDA | cellular_component |
| GO:0000784 | Nuclear chromosome, telomeric region | IC | cellular_component |
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005635 | Nuclear envelope | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006471 | Protein ADP-ribosylation | IDA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0032212 | Positive regulation of telomere maintenance via telomerase | IC | biological_process |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0040014 | Regulation of multicellular organism growth | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0070198 | Protein localization to chromosome, telomeric region | IMP | biological_process |
| GO:0070213 | Protein auto-ADP-ribosylation | IDA | biological_process |
| GO:0090263 | Positive regulation of canonical Wnt signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0973333004 | 0.9253468523 | 0.6525496179 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2821280016 |
| GSE13712_SHEAR | Up | 0.0450477582 |
| GSE13712_STATIC | Down | -0.0842240394 |
| GSE19018 | Down | -0.0561210232 |
| GSE19899_A1 | Up | 0.0743801380 |
| GSE19899_A2 | Up | 0.0582145680 |
| PubMed_21979375_A1 | Up | 0.4482913430 |
| PubMed_21979375_A2 | Up | 0.3753016077 |
| GSE35957 | Up | 0.2961704850 |
| GSE36640 | Up | 0.2820626004 |
| GSE54402 | Up | 0.0886304205 |
| GSE9593 | Up | 0.3844065760 |
| GSE43922 | Up | 0.2040794788 |
| GSE24585 | Up | 0.2092561924 |
| GSE37065 | Up | 0.1886490180 |
| GSE28863_A1 | Down | -0.0528128878 |
| GSE28863_A2 | Up | 0.3004679721 |
| GSE28863_A3 | Down | -0.8410482284 |
| GSE28863_A4 | Up | 0.0674911304 |
| GSE48662 | Up | 0.0458680825 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018499 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-31-3p | MIMAT0004504 | MIRT038941 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-454-5p | MIMAT0003884 | MIRT039255 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30e-5p | MIMAT0000692 | MIRT044139 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046944 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16507984 | Human TRF1 interacts with tankyrase 1 and tankyrase 2 proteins, two related members of the tankyrase family shown to have poly(ADP-ribose) polymerase activity |
| 16507984 | Human tankyrase 2 is proposed to have activity similar to that of tankyrase 1, although tankyrase 2 function has been less extensively characterized |
| 16507984 | In the present study, we have assessed the in vivo function of mouse tankyrase 2 by germ line gene inactivation and show that inactivation of tankyrase 2 does not result in detectable alteration in telomere length when monitored through multiple generations of breeding |
| 16507984 | This finding suggests that either mouse tankyrases 1 and 2 have redundant functions in telomere length maintenance or that mouse tankyrase 2 differs from human tankyrase 2 in its role in telomere length maintenance |
| 16507984 | Tankyrase 2 deficiency did result in a significant decrease in body weight sustained through at least the first year of life, most marked in male mice, suggesting that tankyrase 2 functions in potentially telomerase-independent pathways to affect overall development and/or metabolism |
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