HCSGD entry for STAM
1. General information
| Official gene symbol | STAM |
|---|---|
| Entrez ID | 8027 |
| Gene full name | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 |
| Other gene symbols | STAM-1 STAM1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006886 | Intracellular protein transport | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0009967 | Positive regulation of signal transduction | TAS | biological_process |
| GO:0016197 | Endosomal transport | TAS | biological_process |
| GO:0031901 | Early endosome membrane | IEA | cellular_component |
| GO:0042059 | Negative regulation of epidermal growth factor receptor signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0425302230 | 0.9715611033 | 0.4605119704 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3979368098 |
| GSE13712_SHEAR | Up | 0.0080069940 |
| GSE13712_STATIC | Up | 0.1618822134 |
| GSE19018 | Down | -0.0289434505 |
| GSE19899_A1 | Up | 0.2840000067 |
| GSE19899_A2 | Up | 0.5534828711 |
| PubMed_21979375_A1 | Up | 0.5396254721 |
| PubMed_21979375_A2 | Up | 0.5017466705 |
| GSE35957 | Up | 0.2941281865 |
| GSE36640 | Up | 0.4515199244 |
| GSE54402 | Down | -0.0753741540 |
| GSE9593 | Up | 0.4180118973 |
| GSE43922 | Down | -0.0461785402 |
| GSE24585 | Up | 0.1792332854 |
| GSE37065 | Up | 0.0982899121 |
| GSE28863_A1 | Down | -0.1318824695 |
| GSE28863_A2 | Up | 0.5357842162 |
| GSE28863_A3 | Down | -0.2009528970 |
| GSE28863_A4 | Up | 0.2277354756 |
| GSE48662 | Down | -0.0266868085 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024512 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026819 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051525 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22370639 | The tumor-suppressive effect of ZNF331 is mediated at least by downregulation of genes involved in cell growth promotion (DSTN, EIF5A, GARS, DDX5, STAM, UQCRFS1 and SET) and migration/invasion (DSTN and ACTR3), and upregulation of genome-stability gene (SSBP1) and cellular senescence gene (PNPT1) |
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