HCSGD entry for EDEM3
1. General information
| Official gene symbol | EDEM3 |
|---|---|
| Entrez ID | 80267 |
| Gene full name | ER degradation enhancer, mannosidase alpha-like 3 |
| Other gene symbols | C1orf22 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004190 | Aspartic-type endopeptidase activity | IEA | molecular_function |
| GO:0004569 | Glycoprotein endo-alpha-1,2-mannosidase activity | IEA | molecular_function |
| GO:0004571 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005788 | Endoplasmic reticulum lumen | IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006457 | Protein folding | TAS | biological_process |
| GO:0006516 | Glycoprotein catabolic process | IEA | biological_process |
| GO:0006986 | Response to unfolded protein | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0018279 | Protein N-linked glycosylation via asparagine | TAS | biological_process |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0043687 | Post-translational protein modification | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0082579385 | 0.9226797120 | 0.2352350649 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0302978238 |
| GSE13712_SHEAR | Up | 0.0421178056 |
| GSE13712_STATIC | Down | -0.0883295917 |
| GSE19018 | Down | -0.2513507798 |
| GSE19899_A1 | Up | 1.2146764519 |
| GSE19899_A2 | Up | 0.5019650611 |
| PubMed_21979375_A1 | Down | -0.0851952855 |
| PubMed_21979375_A2 | Up | 0.6258425296 |
| GSE35957 | Up | 0.3536879616 |
| GSE36640 | Up | 1.0234359480 |
| GSE54402 | Up | 0.3314297152 |
| GSE9593 | Up | 0.1822441985 |
| GSE43922 | Up | 0.8130862933 |
| GSE24585 | Up | 0.0610755074 |
| GSE37065 | Up | 0.3354246416 |
| GSE28863_A1 | Up | 0.4898517772 |
| GSE28863_A2 | Up | 0.9570365398 |
| GSE28863_A3 | Down | -0.7319553299 |
| GSE28863_A4 | Down | -0.2764352895 |
| GSE48662 | Up | 0.2434159805 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT005222 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT005245 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018172 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-142-3p | MIMAT0000434 | MIRT021628 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
