HCSGD entry for PREX2

1. General information

Official gene symbolPREX2
Entrez ID80243
Gene full namephosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Other gene symbols6230420N16Rik DEP.2 DEPDC2 P-REX2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0030675Rac GTPase activator activityIDAmolecular_function
GO:0030676Rac guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0032314Regulation of Rac GTPase activityIDAbiological_process
GO:0032318Regulation of Ras GTPase activityIDAbiological_process
GO:0032319Regulation of Rho GTPase activityIDAbiological_process
GO:0032320Positive regulation of Ras GTPase activityIDAbiological_process
GO:0032321Positive regulation of Rho GTPase activityIDAbiological_process
GO:0032855Positive regulation of Rac GTPase activityIDAbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0043087Regulation of GTPase activityIDAbiological_process
GO:0043547Positive regulation of GTPase activityIDAbiological_process
GO:0050790Regulation of catalytic activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41818913040.55568402040.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0512518570
GSE13712_SHEARDown-0.5176747583
GSE13712_STATICDown-0.1907128537
GSE19018Up0.0967382453
GSE19899_A1Up0.0268097989
GSE19899_A2Up0.1239307831
PubMed_21979375_A1Up0.2090889726
PubMed_21979375_A2Up0.0754227323
GSE35957Up0.0454945832
GSE36640Up0.0245261095
GSE54402Up0.1115901706
GSE9593Down-0.1220109978
GSE43922Up0.0159187503
GSE24585Down-0.8798041274
GSE37065Down-0.0087265764
GSE28863_A1Up0.1721794747
GSE28863_A2Up0.7822461509
GSE28863_A3Up0.1908409743
GSE28863_A4Up0.0700775875
GSE48662Up0.2257901229

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018971MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.