HCSGD entry for SPG11
1. General information
| Official gene symbol | SPG11 |
|---|---|
| Entrez ID | 80208 |
| Gene full name | spastic paraplegia 11 (autosomal recessive) |
| Other gene symbols | KIAA1840 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0031410 | Cytoplasmic vesicle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7869220622 | 0.7818256791 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1054559257 |
| GSE13712_SHEAR | Up | 0.2104018991 |
| GSE13712_STATIC | Up | 0.1317325123 |
| GSE19018 | Up | 0.0499819648 |
| GSE19899_A1 | Down | -0.0249796893 |
| GSE19899_A2 | Up | 0.0196349106 |
| PubMed_21979375_A1 | Up | 0.0710884089 |
| PubMed_21979375_A2 | Up | 0.1202660628 |
| GSE35957 | Up | 0.0878754641 |
| GSE36640 | Up | 0.0393756337 |
| GSE54402 | Down | -0.2863131305 |
| GSE9593 | Up | 0.0300866838 |
| GSE43922 | Down | -0.1392708863 |
| GSE24585 | Up | 0.1793132849 |
| GSE37065 | Up | 0.0419797365 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.0452545878 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT030959 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT050465 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
