HCSGD entry for MUS81
1. General information
| Official gene symbol | MUS81 |
|---|---|
| Entrez ID | 80198 |
| Gene full name | MUS81 structure-specific endonuclease |
| Other gene symbols | SLX3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000737 | DNA catabolic process, endonucleolytic | IMP | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004518 | Nuclease activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0006259 | DNA metabolic process | IEA | biological_process |
| GO:0006281 | DNA repair | IEA IMP | biological_process |
| GO:0006308 | DNA catabolic process | IMP | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048257 | 3'-flap endonuclease activity | IMP | molecular_function |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9845067019 | 0.0399913529 | 0.9999902473 | 0.3771452526 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2667751301 |
| GSE13712_SHEAR | Down | -0.2165610092 |
| GSE13712_STATIC | Down | -0.2900389410 |
| GSE19018 | Down | -0.4993036406 |
| GSE19899_A1 | Down | -0.2180374442 |
| GSE19899_A2 | Down | -0.4403366089 |
| PubMed_21979375_A1 | Up | 0.2317646465 |
| PubMed_21979375_A2 | Up | 0.1787070433 |
| GSE35957 | Down | -0.7812675071 |
| GSE36640 | Down | -0.8657652927 |
| GSE54402 | Up | 0.0248055317 |
| GSE9593 | Down | -0.4755040435 |
| GSE43922 | Up | 0.0498568996 |
| GSE24585 | Up | 0.0643722438 |
| GSE37065 | Down | -0.2929896828 |
| GSE28863_A1 | Down | -0.0031151794 |
| GSE28863_A2 | Down | -0.0789457984 |
| GSE28863_A3 | Down | -0.1057406720 |
| GSE28863_A4 | Up | 0.0001803276 |
| GSE48662 | Down | -0.2077918341 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020863 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27255997 | MUS81 is associated with cell proliferation and cisplatin sensitivity in serous ovarian cancer |
| 27255997 | MUS81 is a member of the conserved xeroderma pigmentosum group F (XPF) family protein of endonucleases, which is important to the DDR pathway |
| 27255997 | However, the role of MUS81 in the development of ovarian cancer remains uncertain |
| 27255997 | To explore the expression of MUS81 and its association to serous ovarian cancer (SOC), 43 biopsies of SOC patients were detected by qRT-PCR, and 29 specimens were further performed by immunohistochemistry analysis |
| 27255997 | Here, we observed that MUS81 was over-expressed in SOC tissues at both transcript and protein levels, and the expression level of MUS81 protein in ovarian cancer cell lines was also higher than that in human normal ovarian surface epithelial cell line (HOSEpiC) |
| 27255997 | We also found that down-regulation of MUS81 expression in ovarian cancer cells inhibited cell proliferation and colony formation ability, and influenced cell cycle progression |
| 27255997 | Moreover, inhibition of MUS81 expression induced cellular senescence and enhanced the antitumor effect of cisplatin |
| 27255997 | Down-regulation of MUS81 expression could suppress the growth and development of SOC |
| 27255997 | These results indicate that MUS81 might play important roles in the progression of SOC and influence the antitumor effect of cisplatin |
| 26415217 | Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response |
| 26415217 | The MUS81 protein belongs to a conserved family of DNA structure-specific nucleases that play important roles in DNA replication and repair |
| 26415217 | Inactivation of the Mus81 gene in mice has no major deleterious consequences for embryonic development, although cancer susceptibility has been reported |
| 26415217 | We have investigated the role of MUS81 in human cells by acutely depleting the protein using shRNAs |
| 26415217 | We found that MUS81 depletion from human fibroblasts leads to accumulation of ssDNA and a constitutive DNA damage response that ultimately activates cellular senescence |
| 26415217 | Moreover, we show that MUS81 is required for efficient replication fork progression during an unperturbed S-phase, and for recovery of productive replication following replication stalling |
| 26415217 | These results demonstrate essential roles for the MUS81 nuclease in maintenance of replication fork integrity |
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