HCSGD entry for PTGES2
1. General information
| Official gene symbol | PTGES2 |
|---|---|
| Entrez ID | 80142 |
| Gene full name | prostaglandin E synthase 2 |
| Other gene symbols | C9orf15 GBF-1 GBF1 PGES2 mPGES-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0001516 | Prostaglandin biosynthetic process | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0009055 | Electron carrier activity | IEA | molecular_function |
| GO:0015035 | Protein disulfide oxidoreductase activity | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016829 | Lyase activity | ISS | molecular_function |
| GO:0020037 | Heme binding | ISS | molecular_function |
| GO:0043295 | Glutathione binding | ISS | molecular_function |
| GO:0045454 | Cell redox homeostasis | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0046903 | Secretion | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0050220 | Prostaglandin-E synthase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6304113863 | 0.3330344782 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1551227762 |
| GSE13712_SHEAR | Up | 0.1081812333 |
| GSE13712_STATIC | Up | 0.5257787803 |
| GSE19018 | Up | 0.1221002666 |
| GSE19899_A1 | Down | -0.1718763269 |
| GSE19899_A2 | Up | 0.2424788618 |
| PubMed_21979375_A1 | Up | 0.1408129069 |
| PubMed_21979375_A2 | Down | -0.0591340978 |
| GSE35957 | Up | 0.0505858065 |
| GSE36640 | Up | 0.0055724616 |
| GSE54402 | Up | 0.1328214978 |
| GSE9593 | Down | -0.5668231653 |
| GSE43922 | Up | 0.0471730947 |
| GSE24585 | Down | -0.4662628861 |
| GSE37065 | Down | -0.1578335851 |
| GSE28863_A1 | Down | -0.1668325406 |
| GSE28863_A2 | Down | -0.1805142044 |
| GSE28863_A3 | Down | -0.0265297361 |
| GSE28863_A4 | Down | -0.1066448223 |
| GSE48662 | Up | 0.2475840546 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016466 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028318 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051829 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052205 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052529 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
