HCSGD entry for PIF1
1. General information
| Official gene symbol | PIF1 |
|---|---|
| Entrez ID | 80119 |
| Gene full name | PIF1 5'-to-3' DNA helicase |
| Other gene symbols | C15orf20 PIF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000002 | Mitochondrial genome maintenance | IEA | biological_process |
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0000723 | Telomere maintenance | IEA | biological_process |
| GO:0000784 | Nuclear chromosome, telomeric region | IDA | cellular_component |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0010521 | Telomerase inhibitor activity | IEA | molecular_function |
| GO:0017116 | Single-stranded DNA-dependent ATP-dependent DNA helicase activity | IDA | molecular_function |
| GO:0032204 | Regulation of telomere maintenance | IDA | biological_process |
| GO:0032211 | Negative regulation of telomere maintenance via telomerase | IEA | biological_process |
| GO:0032508 | DNA duplex unwinding | IDA | biological_process |
| GO:0033682 | ATP-dependent 5'-3' DNA/RNA helicase activity | IDA | molecular_function |
| GO:0042162 | Telomeric DNA binding | IDA | molecular_function |
| GO:0043141 | ATP-dependent 5'-3' DNA helicase activity | IDA | molecular_function |
| GO:0051880 | G-quadruplex DNA binding | IEA | molecular_function |
| GO:0051974 | Negative regulation of telomerase activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9794574522 | 0.0335546408 | 0.9999902473 | 0.3458072435 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1031813624 |
| GSE13712_SHEAR | Down | -0.0610300135 |
| GSE13712_STATIC | Down | -0.0763306455 |
| GSE19018 | Up | 0.0469153634 |
| GSE19899_A1 | Down | -0.0927739264 |
| GSE19899_A2 | Down | -0.7952958948 |
| PubMed_21979375_A1 | Down | -0.6827406371 |
| PubMed_21979375_A2 | Down | -0.4312194957 |
| GSE35957 | Down | -0.0581944689 |
| GSE36640 | Down | -1.4702628354 |
| GSE54402 | Down | -0.4004037842 |
| GSE9593 | Down | -0.2546065505 |
| GSE43922 | Up | 0.0554035553 |
| GSE24585 | Down | -0.0721532106 |
| GSE37065 | Down | -0.0252176360 |
| GSE28863_A1 | Down | -0.2006160271 |
| GSE28863_A2 | Down | -0.2316383699 |
| GSE28863_A3 | Up | 0.2086273780 |
| GSE28863_A4 | Up | 0.1698570070 |
| GSE48662 | Down | -0.4155258137 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024811 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026839 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
