HCSGD entry for NRSN2
1. General information
| Official gene symbol | NRSN2 |
|---|---|
| Entrez ID | 80023 |
| Gene full name | neurensin 2 |
| Other gene symbols | C20orf98 dJ1103G7.6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030133 | Transport vesicle | ISS | cellular_component |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2117358611 | 0.4617481517 | 0.8870125099 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0248383065 |
| GSE13712_SHEAR | Up | 0.3202932718 |
| GSE13712_STATIC | Up | 0.0604244595 |
| GSE19018 | Down | -0.0133481160 |
| GSE19899_A1 | Down | -0.1247922567 |
| GSE19899_A2 | Up | 0.0662537622 |
| PubMed_21979375_A1 | Up | 0.0990976248 |
| PubMed_21979375_A2 | Up | 2.3591025658 |
| GSE35957 | Up | 0.0863936354 |
| GSE36640 | Up | 0.4759143271 |
| GSE54402 | Down | -0.0156372232 |
| GSE9593 | Up | 0.1198058718 |
| GSE43922 | Down | -0.0575122151 |
| GSE24585 | Up | 0.1990765675 |
| GSE37065 | Down | -0.2671988085 |
| GSE28863_A1 | Down | -0.1778362741 |
| GSE28863_A2 | Down | -0.2584036157 |
| GSE28863_A3 | Up | 0.0470392382 |
| GSE28863_A4 | Down | -0.0317586980 |
| GSE48662 | Up | 0.2008404592 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025872 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-671-5p | MIMAT0003880 | MIRT039265 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043401 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051533 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26055238 | In the current study, we aimed to investigate the biological functions and possible mechanisms of neurensin-2 |
| 26055238 | Both loss and gain function assays revealed that NRSN2 inhibits cancer cell proliferation and promotes cancer cell senescence and apoptosis |
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