HCSGD entry for OBFC1
1. General information
| Official gene symbol | OBFC1 |
|---|---|
| Entrez ID | 79991 |
| Gene full name | oligonucleotide/oligosaccharide-binding fold containing 1 |
| Other gene symbols | AAF-44 AAF44 RP11-541N10.2 RPA-32 STN1 bA541N10.2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000723 | Telomere maintenance | IMP | biological_process |
| GO:0000784 | Nuclear chromosome, telomeric region | IDA | cellular_component |
| GO:0003697 | Single-stranded DNA binding | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA ISS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0010833 | Telomere maintenance via telomere lengthening | IMP | biological_process |
| GO:0043047 | Single-stranded telomeric DNA binding | IDA | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0045111 | Intermediate filament cytoskeleton | IDA | cellular_component |
| GO:0045740 | Positive regulation of DNA replication | ISS | biological_process |
| GO:0070188 | Stn1-Ten1 complex | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0173148931 | 0.9743967668 | 0.3241304193 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0059761105 |
| GSE13712_SHEAR | Up | 0.7332415475 |
| GSE13712_STATIC | Up | 0.4991240355 |
| GSE19018 | Up | 0.1435524273 |
| GSE19899_A1 | Up | 0.2209411697 |
| GSE19899_A2 | Up | 0.4110470101 |
| PubMed_21979375_A1 | Up | 0.2089376487 |
| PubMed_21979375_A2 | Up | 0.3443805739 |
| GSE35957 | Down | -0.0166855920 |
| GSE36640 | Up | 0.5478509597 |
| GSE54402 | Up | 0.0859873609 |
| GSE9593 | Up | 0.2092559548 |
| GSE43922 | Up | 0.1638558806 |
| GSE24585 | Up | 1.2312126239 |
| GSE37065 | Down | -0.0530628704 |
| GSE28863_A1 | Up | 0.4941827820 |
| GSE28863_A2 | Up | 0.2975404198 |
| GSE28863_A3 | Down | -0.2964137308 |
| GSE28863_A4 | Down | -0.2329344108 |
| GSE48662 | Up | 0.0629899551 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24478790 | Many studies have shown that leukocyte telomere length is a heritable trait, and several candidate genes have been identified, including TERT, TERC, OBFC1, and CTC1 |
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