HCSGD entry for WLS
1. General information
| Official gene symbol | WLS |
|---|---|
| Entrez ID | 79971 |
| Gene full name | wntless homolog (Drosophila) |
| Other gene symbols | C1orf139 EVI GPR177 MRP mig-14 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0001707 | Mesoderm formation | IEA | biological_process |
| GO:0004871 | Signal transducer activity | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0009948 | Anterior/posterior axis specification | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0017147 | Wnt-protein binding | IEA | molecular_function |
| GO:0030659 | Cytoplasmic vesicle membrane | IEA | cellular_component |
| GO:0031410 | Cytoplasmic vesicle | IEA | cellular_component |
| GO:0031901 | Early endosome membrane | TAS | cellular_component |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | ISS | biological_process |
| GO:0090263 | Positive regulation of canonical Wnt signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0003894343 | 0.9815296607 | 0.0518261307 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 2.2605261810 |
| GSE13712_SHEAR | Down | -0.0446475500 |
| GSE13712_STATIC | Up | 0.0375869359 |
| GSE19018 | Down | -0.3903406333 |
| GSE19899_A1 | Up | 2.2946048350 |
| GSE19899_A2 | Up | 1.3133447803 |
| PubMed_21979375_A1 | Up | 1.0582274197 |
| PubMed_21979375_A2 | Up | 1.2705051820 |
| GSE35957 | Up | 0.3890019574 |
| GSE36640 | Up | 1.5252662084 |
| GSE54402 | Up | 0.1089437985 |
| GSE9593 | Up | 0.7915954453 |
| GSE43922 | Up | 1.4732189292 |
| GSE24585 | Up | 0.0481095265 |
| GSE37065 | Up | 0.3940484821 |
| GSE28863_A1 | Up | 0.6776682176 |
| GSE28863_A2 | Up | 1.2433658019 |
| GSE28863_A3 | Down | -0.0371345645 |
| GSE28863_A4 | Down | -0.3133519945 |
| GSE48662 | Down | -0.0629431630 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023503 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028895 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032212 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044935 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
