HCSGD entry for LPCAT1
1. General information
| Official gene symbol | LPCAT1 |
|---|---|
| Entrez ID | 79888 |
| Gene full name | lysophosphatidylcholine acyltransferase 1 |
| Other gene symbols | AYTL2 PFAAP3 lpcat |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA ISS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005794 | Golgi apparatus | ISS | cellular_component |
| GO:0005811 | Lipid particle | IDA | cellular_component |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006654 | Phosphatidic acid biosynthetic process | TAS | biological_process |
| GO:0008654 | Phospholipid biosynthetic process | ISS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019432 | Triglyceride biosynthetic process | TAS | biological_process |
| GO:0036148 | Phosphatidylglycerol acyl-chain remodeling | TAS | biological_process |
| GO:0036151 | Phosphatidylcholine acyl-chain remodeling | IDA TAS | biological_process |
| GO:0043129 | Surfactant homeostasis | IEA | biological_process |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045732 | Positive regulation of protein catabolic process | IEA | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
| GO:0047159 | 1-alkenylglycerophosphocholine O-acyltransferase activity | IEA | molecular_function |
| GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity | IDA ISS | molecular_function |
| GO:0047191 | 1-alkylglycerophosphocholine O-acyltransferase activity | IEA | molecular_function |
| GO:0047192 | 1-alkylglycerophosphocholine O-acetyltransferase activity | IEA | molecular_function |
| GO:0060041 | Retina development in camera-type eye | IEA | biological_process |
| GO:2001246 | Negative regulation of phosphatidylcholine biosynthetic process | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0964545040 | 0.6375642415 | 0.6491022222 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5195936574 |
| GSE13712_SHEAR | Down | -0.1157753620 |
| GSE13712_STATIC | Down | -0.1545474004 |
| GSE19018 | Down | -0.3188072559 |
| GSE19899_A1 | Down | -0.3550072707 |
| GSE19899_A2 | Up | 0.4747385665 |
| PubMed_21979375_A1 | Up | 0.7140400012 |
| PubMed_21979375_A2 | Up | 0.5721271304 |
| GSE35957 | Down | -0.7292022929 |
| GSE36640 | Up | 0.2527971814 |
| GSE54402 | Up | 0.2929050412 |
| GSE9593 | Up | 0.0803835329 |
| GSE43922 | Up | 0.4984354706 |
| GSE24585 | Down | -0.2058972372 |
| GSE37065 | Down | -0.2173392978 |
| GSE28863_A1 | Up | 0.1383578597 |
| GSE28863_A2 | Up | 0.5077701751 |
| GSE28863_A3 | Up | 0.2340873328 |
| GSE28863_A4 | Down | -0.0740029411 |
| GSE48662 | Down | -0.1125615434 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016594 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018810 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019629 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-375 | MIMAT0000728 | MIRT020006 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030129 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045068 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26881843 | In H2O2-treated oocytes, the expression of lysophosphatidylcholine acyltransferase 1 increased along with increases in phosphatidylcholine |
Entries Per Page
Displaying Page of
