HCSGD entry for KDM8
1. General information
| Official gene symbol | KDM8 |
|---|---|
| Entrez ID | 79831 |
| Gene full name | lysine (K)-specific demethylase 8 |
| Other gene symbols | JMJD5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | IMP | biological_process |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051864 | Histone demethylase activity (H3-K36 specific) | IDA | molecular_function |
| GO:0070544 | Histone H3-K36 demethylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9284846700 | 0.3612918316 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1119218113 |
| GSE13712_SHEAR | Down | -0.1528165781 |
| GSE13712_STATIC | Down | -0.1117286551 |
| GSE19018 | Down | -0.0316358177 |
| GSE19899_A1 | Up | 0.1076361724 |
| GSE19899_A2 | Up | 0.0493339089 |
| PubMed_21979375_A1 | Up | 0.0160293466 |
| PubMed_21979375_A2 | Down | -0.1266193743 |
| GSE35957 | Down | -0.0221527617 |
| GSE36640 | Up | 0.0436750811 |
| GSE54402 | Down | -0.0670416220 |
| GSE9593 | Up | 0.0677170044 |
| GSE43922 | Up | 0.0415679075 |
| GSE24585 | Down | -0.1742626490 |
| GSE37065 | Down | -0.1614647328 |
| GSE28863_A1 | Down | -0.0665742029 |
| GSE28863_A2 | Down | -0.0693250415 |
| GSE28863_A3 | Up | 0.0405019468 |
| GSE28863_A4 | Down | -0.0741166441 |
| GSE48662 | Up | 0.0996465837 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-149-5p | MIMAT0000450 | MIRT045429 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378c | MIMAT0016847 | MIRT052832 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
