HCSGD entry for LIN28A

1. General information

Official gene symbolLIN28A
Entrez ID79727
Gene full namelin-28 homolog A (C. elegans)
Other gene symbolsCSDD1 LIN-28 LIN28 ZCCHC1 lin-28A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000932Cytoplasmic mRNA processing bodyIDAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0003723RNA bindingIDAmolecular_function
GO:0003729MRNA bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0007281Germ cell developmentIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010494Cytoplasmic stress granuleIDAcellular_component
GO:0010587MiRNA catabolic processIMPbiological_process
GO:0019827Stem cell maintenanceIMPbiological_process
GO:0031054Pre-miRNA processingIMPbiological_process
GO:0031123RNA 3'-end processingIMPbiological_process
GO:0031369Translation initiation factor bindingIEAmolecular_function
GO:0035198MiRNA bindingIEAmolecular_function
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045686Negative regulation of glial cell differentiationIEAbiological_process
GO:0045727Positive regulation of translationIEAbiological_process
GO:0060964Regulation of gene silencing by miRNAIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.45104741080.61671390520.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1664710028
GSE13712_SHEARDown-0.2205162747
GSE13712_STATICUp0.3218081731
GSE19018Up0.2438188210
GSE19899_A1Up0.2636757808
GSE19899_A2Up0.0378210479
PubMed_21979375_A1Up0.2120312057
PubMed_21979375_A2Up0.3310218199
GSE35957Down-0.1946839231
GSE36640Down-0.2778889470
GSE54402Up0.0074126980
GSE9593Down-0.1445276160
GSE43922Up0.0192133127
GSE24585Down-0.1016486940
GSE37065Down-0.0321186585
GSE28863_A1Down-0.2896096723
GSE28863_A2Down-0.4379721915
GSE28863_A3Up0.1842623673
GSE28863_A4Up0.0605371069
GSE48662Up0.1450318640

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125a-5pMIMAT0000443MIRT003738Luciferase reporter assayFunctional MTI16227573
hsa-miR-125b-5pMIMAT0000423MIRT003845Reporter assayFunctional MTI18230348
hsa-miR-125b-5pMIMAT0000423MIRT003845B-globin reporter assay//Luciferase reporter assayFunctional MTI16495412
hsa-miR-125b-5pMIMAT0000423MIRT003845Luciferase reporter assayFunctional MTI16227573
hsa-miR-125b-5pMIMAT0000423MIRT003845Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22366319
hsa-let-7b-5pMIMAT0000063MIRT004011Luciferase reporter assay//Reporter assayFunctional MTI15131085
hsa-let-7a-5pMIMAT0000062MIRT004801B-globin reporter assay//Luciferase reporter assay//MicroarrayFunctional MTI16495412
hsa-miR-335-5pMIMAT0000765MIRT017319MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT022327MicroarrayFunctional MTI (Weak)18668037
hsa-miR-26b-5pMIMAT0000083MIRT029116MicroarrayFunctional MTI (Weak)19088304
Entries Per Page
Displaying Page of
    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-let-7b-5pMIMAT00000631hsa-let-7b15131085
hsa-miR-125b-5pMIMAT0000423NAhsa-miR-125b18230348
hsa-miR-125b-5pMIMAT00004232hsa-miR-125b16495412
hsa-miR-125b-5pMIMAT00004231hsa-miR-125b16495412
hsa-let-7a-5pMIMAT0000062NAhsa-let-7a16495412
hsa-miR-125a-5pMIMAT00004432hsa-miR-125a-5p16227573
hsa-miR-125a-5pMIMAT00004431hsa-miR-125a-5p16227573
hsa-miR-125b-5pMIMAT00004232hsa-miR-125b{Western blot}{Western blot}{underexpression by 2'-O-Me antisense miRNA oligonucleotides}{overexpression by miRNA precursor transfection}16227573
hsa-miR-125b-5pMIMAT00004231hsa-miR-125b{Western blot}{Western blot}{underexpression by 2'-O-Me antisense miRNA oligonucleotides}{overexpression by miRNA precursor transfection}16227573
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24763337Introduction of "reprogramming factors", Oct4, Sox2, Klf4, cMyc and Lin28, into senescent fibroblasts and measuring the changes in HP1beta mobility as reprogramming proceeds shows that the mobility of HP1beta in senescent cells increases and by day 9 is the same as that found in young fibroblasts
20512147Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies
20512147LIN28B and its homolog LIN28A are functionally redundant RNA-binding proteins that block biogenesis of let-7 microRNAs
20512147To explore the function of the Lin28-Let-7 pathway in vivo, we engineered transgenic mice to express Lin28a and observed in them increased body size, crown-rump length and delayed onset of puberty
Entries Per Page
Displaying Page of