HCSGD entry for LRRK1
1. General information
| Official gene symbol | LRRK1 |
|---|---|
| Entrez ID | 79705 |
| Gene full name | leucine-rich repeat kinase 1 |
| Other gene symbols | RIPK6 Roco1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5713135709 | 0.0556646404 | 0.9999902473 | 0.4439845455 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0976028331 |
| GSE13712_SHEAR | Down | -0.0011527135 |
| GSE13712_STATIC | Up | 0.2163512910 |
| GSE19018 | Up | 0.1561874747 |
| GSE19899_A1 | Down | -0.2214638016 |
| GSE19899_A2 | Down | -0.3815354756 |
| PubMed_21979375_A1 | Down | -0.3740791789 |
| PubMed_21979375_A2 | Down | -0.2112994598 |
| GSE35957 | Down | -0.4891713797 |
| GSE36640 | Down | -1.0742379718 |
| GSE54402 | Down | -0.4332972214 |
| GSE9593 | Down | -0.1040101180 |
| GSE43922 | Down | -0.7620934220 |
| GSE24585 | Up | 0.1318085095 |
| GSE37065 | Down | -0.2783956590 |
| GSE28863_A1 | Up | 1.1013517533 |
| GSE28863_A2 | Up | 0.9216818179 |
| GSE28863_A3 | Down | -0.1035841206 |
| GSE28863_A4 | Up | 0.0622109301 |
| GSE48662 | Down | -0.2763731094 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
