HCSGD entry for CDC73

1. General information

Official gene symbolCDC73
Entrez ID79577
Gene full namecell division cycle 73
Other gene symbolsC1orf28 HPTJT HRPT2 HYX
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0000993RNA polymerase II core bindingIDAmolecular_function
GO:0001711Endodermal cell fate commitmentISSbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006378MRNA polyadenylationIMPbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0010390Histone monoubiquitinationIDAbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0016593Cdc73/Paf1 complexIDAcellular_component
GO:0019827Stem cell maintenanceISSbiological_process
GO:0030177Positive regulation of Wnt signaling pathwayIDAbiological_process
GO:0031442Positive regulation of mRNA 3'-end processingIMPbiological_process
GO:0031648Protein destabilizationIMPbiological_process
GO:0032968Positive regulation of transcription elongation from RNA polymerase II promoterIDAbiological_process
GO:0033523Histone H2B ubiquitinationIDAbiological_process
GO:0045638Negative regulation of myeloid cell differentiationIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048147Negative regulation of fibroblast proliferationIMPbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIMPbiological_process
GO:0071222Cellular response to lipopolysaccharideISSbiological_process
GO:2000134Negative regulation of G1/S transition of mitotic cell cycleIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.44481274650.79376751640.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4474080182
GSE13712_SHEARUp0.1694635057
GSE13712_STATICUp0.1911093432
GSE19018Up0.1337983647
GSE19899_A1Up0.0425343058
GSE19899_A2Down-0.0841454270
PubMed_21979375_A1Up0.1718896084
PubMed_21979375_A2Up0.0307608321
GSE35957Up0.1579198529
GSE36640Down-0.0292781089
GSE54402Up0.0143021749
GSE9593Up0.1871826656
GSE43922Down-0.0461524045
GSE24585Up0.2314180172
GSE37065Up0.1073934174
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.0603698925

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020706ProteomicsFunctional MTI (Weak)18668040
hsa-miR-23b-3pMIMAT0000418MIRT046249CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048545CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.