HCSGD entry for NKAP
1. General information
| Official gene symbol | NKAP |
|---|---|
| Entrez ID | 79576 |
| Gene full name | NFKB activating protein |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007219 | Notch signaling pathway | IEA | biological_process |
| GO:0019827 | Stem cell maintenance | IEA | biological_process |
| GO:0030851 | Granulocyte differentiation | IEA | biological_process |
| GO:0031490 | Chromatin DNA binding | IEA | molecular_function |
| GO:0033077 | T cell differentiation in thymus | IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0046638 | Positive regulation of alpha-beta T cell differentiation | IMP | biological_process |
| GO:0071425 | Hematopoietic stem cell proliferation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3185304814 | 0.6016371794 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0629865119 |
| GSE13712_SHEAR | Down | -0.2582700696 |
| GSE13712_STATIC | Up | 0.0494505679 |
| GSE19018 | Up | 0.1013435345 |
| GSE19899_A1 | Up | 0.3175202629 |
| GSE19899_A2 | Up | 0.7844077571 |
| PubMed_21979375_A1 | Up | 0.2714425969 |
| PubMed_21979375_A2 | Up | 0.3058606418 |
| GSE35957 | Down | -0.4624245320 |
| GSE36640 | Up | 0.0998758802 |
| GSE54402 | Up | 0.1388032851 |
| GSE9593 | Down | -0.3367867488 |
| GSE43922 | Up | 0.0923203308 |
| GSE24585 | Up | 0.1290595887 |
| GSE37065 | Up | 0.1167769267 |
| GSE28863_A1 | Up | 0.1383527046 |
| GSE28863_A2 | Down | -0.3947038920 |
| GSE28863_A3 | Down | -0.3901883927 |
| GSE28863_A4 | Up | 0.0743020353 |
| GSE48662 | Down | -0.1398428628 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT021176 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022503 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
