HCSGD entry for TFEB
1. General information
| Official gene symbol | TFEB |
|---|---|
| Entrez ID | 7942 |
| Gene full name | transcription factor EB |
| Other gene symbols | ALPHATFEB BHLHE35 TCFEB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001892 | Embryonic placenta development | IEA ISS | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA IEA NAS | molecular_function |
| GO:0005634 | Nucleus | IDA NAS | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0006914 | Autophagy | IEA | biological_process |
| GO:0006959 | Humoral immune response | IEA ISS | biological_process |
| GO:0007040 | Lysosome organization | IMP | biological_process |
| GO:0010508 | Positive regulation of autophagy | IMP | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | IDA IEA | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0046983 | Protein dimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5385411535 | 0.6247607120 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0912675659 |
| GSE13712_SHEAR | Down | -0.9269825905 |
| GSE13712_STATIC | Down | -0.0102463724 |
| GSE19018 | Up | 0.1284374635 |
| GSE19899_A1 | Down | -0.0006648880 |
| GSE19899_A2 | Up | 0.1958964260 |
| PubMed_21979375_A1 | Up | 0.1468235365 |
| PubMed_21979375_A2 | Up | 0.1049752020 |
| GSE35957 | Down | -0.0327162288 |
| GSE36640 | Up | 0.4658728360 |
| GSE54402 | Down | -0.0728999901 |
| GSE9593 | Down | -0.0770391094 |
| GSE43922 | Up | 0.0494684943 |
| GSE24585 | Up | 0.0907971848 |
| GSE37065 | Down | -0.0428826764 |
| GSE28863_A1 | Down | -0.1085556452 |
| GSE28863_A2 | Down | -0.0988571697 |
| GSE28863_A3 | Up | 0.0828423961 |
| GSE28863_A4 | Down | -0.0351515385 |
| GSE48662 | Up | 0.5398829542 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023048 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030033 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27153139 | Furthermore, confocal microscopy showed in E-CSC: an accumulation of intralysosomal lipofuscins, a reduction of cathepsin B activity, evidence of lysosome membrane permeabilization, and the reduction of the nuclear active TFEB |
| 27153139 | The use of Rapamycin (TORC1 inhibitor) was able on one hand to increase TFEB activation and, on the other hand, to reduce lipofuscin mass, potentiating the lysosomal functionality |
| 27153139 | CONCLUSIONS: This study demonstrated for the first time that E-CSC are characterized by a blunted activation of TFEB and an altered proteostasis |
| 26003288 | Other MiT members, TFEB and TFE3, are known to play important roles in cellular clearance pathways by transcriptionally regulating the biogenesis of lysosomes and autophagosomes via activation of CLEAR elements in gene promoters of target genes |
| 26003288 | Here we review the role of MiT members, including MITF, in lysosomal biogenesis, and how cancers overexpressing MITF, TFEB or TFE3 could rewire the lysosomal pathway, inhibit cellular senescence, and activate Wnt signaling by increasing sequestration of negative regulators of Wnt signaling in multivesicular bodies (MVBs) |
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