HCSGD entry for NOX5
1. General information
| Official gene symbol | NOX5 |
|---|---|
| Entrez ID | 79400 |
| Gene full name | NADPH oxidase, EF-hand calcium binding domain 5 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000910 | Cytokinesis | NAS | biological_process |
| GO:0001525 | Angiogenesis | IDA IEA | biological_process |
| GO:0001935 | Endothelial cell proliferation | IDA | biological_process |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA IEA | cellular_component |
| GO:0006812 | Cation transport | IDA | biological_process |
| GO:0006915 | Apoptotic process | NAS | biological_process |
| GO:0008283 | Cell proliferation | NAS | biological_process |
| GO:0010155 | Regulation of proton transport | NAS | biological_process |
| GO:0015252 | Hydrogen ion channel activity | IDA | molecular_function |
| GO:0015992 | Proton transport | IDA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016175 | Superoxide-generating NADPH oxidase activity | IDA | molecular_function |
| GO:0020037 | Heme binding | NAS | molecular_function |
| GO:0034220 | Ion transmembrane transport | IDA | biological_process |
| GO:0042554 | Superoxide anion generation | IDA | biological_process |
| GO:0043012 | Regulation of fusion of sperm to egg plasma membrane | NAS | biological_process |
| GO:0050660 | Flavin adenine dinucleotide binding | NAS | molecular_function |
| GO:0050661 | NADP binding | NAS | molecular_function |
| GO:0050663 | Cytokine secretion | NAS | biological_process |
| GO:0055085 | Transmembrane transport | IDA | biological_process |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
| GO:2000379 | Positive regulation of reactive oxygen species metabolic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6039722693 | 0.6549455986 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0260768932 |
| GSE13712_SHEAR | Down | -0.0563295192 |
| GSE13712_STATIC | Up | 0.0674434208 |
| GSE19018 | Up | 0.0645817779 |
| GSE19899_A1 | Up | 0.0821176207 |
| GSE19899_A2 | Up | 0.2920280770 |
| PubMed_21979375_A1 | Up | 0.1016986508 |
| PubMed_21979375_A2 | Down | -0.0612582664 |
| GSE35957 | Up | 0.0825157976 |
| GSE36640 | Up | 0.1871079658 |
| GSE54402 | Up | 0.2188062227 |
| GSE9593 | Down | -0.0744593504 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.1468909657 |
| GSE28863_A2 | Down | -0.3926622931 |
| GSE28863_A3 | Down | -0.3103107607 |
| GSE28863_A4 | Up | 0.0931228175 |
| GSE48662 | Up | 0.0748988027 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21841319 | Translocated NOX5 was correlated with early and rapid ROS production, but it contributed little to EPCs senescence |
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