HCSGD entry for HSD17B8
1. General information
| Official gene symbol | HSD17B8 |
|---|---|
| Entrez ID | 7923 |
| Gene full name | hydroxysteroid (17-beta) dehydrogenase 8 |
| Other gene symbols | D6S2245E FABG FABGL H2-KE6 HKE6 KE6 RING2 SDR30C1 dJ1033B10.9 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity | IDA | molecular_function |
| GO:0004303 | Estradiol 17-beta-dehydrogenase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005740 | Mitochondrial envelope | IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006633 | Fatty acid biosynthetic process | IEA | biological_process |
| GO:0006703 | Estrogen biosynthetic process | IDA IEA | biological_process |
| GO:0008209 | Androgen metabolic process | IEA | biological_process |
| GO:0047035 | Testosterone dehydrogenase (NAD+) activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9284042286 | 0.2650733293 | 0.9999902473 | 0.9867933362 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1998444266 |
| GSE13712_SHEAR | Down | -0.1475248779 |
| GSE13712_STATIC | Down | -0.1653906238 |
| GSE19018 | Up | 0.1368088680 |
| GSE19899_A1 | Down | -0.1975688505 |
| GSE19899_A2 | Down | -0.0075532200 |
| PubMed_21979375_A1 | Down | -0.1047291701 |
| PubMed_21979375_A2 | Down | -0.0723242940 |
| GSE35957 | Up | 0.0635691595 |
| GSE36640 | Down | -0.0359699744 |
| GSE54402 | Down | -0.6337876917 |
| GSE9593 | Down | -0.1623562988 |
| GSE43922 | Up | 0.0115324161 |
| GSE24585 | Up | 0.1011879728 |
| GSE37065 | Up | 0.0689343484 |
| GSE28863_A1 | Down | -0.0341829471 |
| GSE28863_A2 | Up | 0.0684540884 |
| GSE28863_A3 | Up | 0.1000933135 |
| GSE28863_A4 | Up | 0.0224078578 |
| GSE48662 | Up | 0.0322969581 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| 2'-Monophosphoadenosine 5'-Diphosphoribose | DB03461 | EXPT02293 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023823 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031735 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
