HCSGD entry for DERL1
1. General information
| Official gene symbol | DERL1 |
|---|---|
| Entrez ID | 79139 |
| Gene full name | derlin 1 |
| Other gene symbols | DER-1 DER1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004872 | Receptor activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005769 | Early endosome | IEA | cellular_component |
| GO:0005770 | Late endosome | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA IMP | cellular_component |
| GO:0006986 | Response to unfolded protein | IMP | biological_process |
| GO:0016021 | Integral component of membrane | IDA | cellular_component |
| GO:0019060 | Intracellular transport of viral protein in host cell | TAS | biological_process |
| GO:0030176 | Integral component of endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | IDA | biological_process |
| GO:0030970 | Retrograde protein transport, ER to cytosol | IDA IMP | biological_process |
| GO:0034620 | Cellular response to unfolded protein | IEA | biological_process |
| GO:0042288 | MHC class I protein binding | IDA | molecular_function |
| GO:0045184 | Establishment of protein localization | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1862380381 | 0.9417254778 | 0.8418291946 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1720376749 |
| GSE13712_SHEAR | Down | -0.1057910263 |
| GSE13712_STATIC | Up | 0.0748875001 |
| GSE19018 | Up | 0.1810664089 |
| GSE19899_A1 | Up | 0.2848290252 |
| GSE19899_A2 | Up | 0.2474387081 |
| PubMed_21979375_A1 | Down | -0.1419610487 |
| PubMed_21979375_A2 | Up | 0.0149749096 |
| GSE35957 | Down | -0.0422563783 |
| GSE36640 | Up | 0.3649795284 |
| GSE54402 | Down | -0.0166999133 |
| GSE9593 | Up | 0.1469254858 |
| GSE43922 | Up | 0.3352127997 |
| GSE24585 | Up | 0.0189984889 |
| GSE37065 | Up | 0.2268450781 |
| GSE28863_A1 | Up | 0.2367546746 |
| GSE28863_A2 | Up | 0.3203088156 |
| GSE28863_A3 | Down | -0.2862896829 |
| GSE28863_A4 | Down | -0.0309684772 |
| GSE48662 | Down | -0.3327146957 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT000172 | Luciferase reporter assay//Quantitative proteomic approach | Functional MTI | 19253296 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT000172 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028468 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031154 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT050045 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
