HCSGD entry for MAPKAP1
1. General information
| Official gene symbol | MAPKAP1 |
|---|---|
| Entrez ID | 79109 |
| Gene full name | mitogen-activated protein kinase associated protein 1 |
| Other gene symbols | JC310 MIP1 SIN1 SIN1b SIN1g |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005546 | Phosphatidylinositol-4,5-bisphosphate binding | IDA | molecular_function |
| GO:0005547 | Phosphatidylinositol-3,4,5-trisphosphate binding | IDA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0017016 | Ras GTPase binding | IDA | molecular_function |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0043325 | Phosphatidylinositol-3,4-bisphosphate binding | IDA | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0046580 | Negative regulation of Ras protein signal transduction | IMP | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0070300 | Phosphatidic acid binding | IDA | molecular_function |
| GO:0080025 | Phosphatidylinositol-3,5-bisphosphate binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0528818358 | 0.9631367235 | 0.5025707220 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1770187191 |
| GSE13712_SHEAR | Up | 0.1868561877 |
| GSE13712_STATIC | Up | 0.2203842970 |
| GSE19018 | Up | 0.2764341334 |
| GSE19899_A1 | Up | 0.1686484819 |
| GSE19899_A2 | Up | 0.8175052695 |
| PubMed_21979375_A1 | Up | 0.8771632098 |
| PubMed_21979375_A2 | Up | 0.4121733263 |
| GSE35957 | Up | 0.0637633481 |
| GSE36640 | Up | 0.2354201710 |
| GSE54402 | Up | 0.6650836564 |
| GSE9593 | Up | 0.2772870094 |
| GSE43922 | Up | 0.0191921178 |
| GSE24585 | Down | -0.2261123802 |
| GSE37065 | Down | -0.0542928702 |
| GSE28863_A1 | Down | -0.0566864942 |
| GSE28863_A2 | Up | 0.0487332107 |
| GSE28863_A3 | Down | -0.2779965163 |
| GSE28863_A4 | Up | 0.1043896775 |
| GSE48662 | Down | -0.1503553822 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019887 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029925 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25476852 | We found that incubation of purified recombinant Sirt6 protein with 3-morpholinosydnonimine (SIN-1; a peroxynitrite donor that generates nitric oxide and superoxide simultaneously) increased Sirt6 tyrosine nitration and decreased its intrinsic catalytic activity |
| 25476852 | Similar results were observed in SIN-1-treated Sirt6, which was overexpressed in HEK293 cells, and in endogenous Sirt6 when human retinal microvascular endothelial cells were treated with SIN-1 |
| 25476852 | With mass spectrometry, we identified that tyrosine 257 in Sirt6 was nitrated after SIN-1 treatment |
| 25476852 | Mass spectrometry analysis also revealed oxidation of methionine and tryptophan in Sirt6 after SIN-1 treatment |
| 25175370 | Of note, pretreatment with 3morpholinosydnonimine hydrochloride (SIN1), an inducer of HO1 expression, markedly attenuated cilostazolinduced chondrocyte senescence, and thus, we examined whether HO1 directly modulates chondrocyte senescence induced by cilostazol |
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