HCSGD entry for MANF
1. General information
| Official gene symbol | MANF |
|---|---|
| Entrez ID | 7873 |
| Gene full name | mesencephalic astrocyte-derived neurotrophic factor |
| Other gene symbols | ARMET ARP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002014 | Vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure | IEA | biological_process |
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006986 | Response to unfolded protein | IEA | biological_process |
| GO:0008083 | Growth factor activity | IEA | molecular_function |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9438153946 | 0.0211081494 | 0.9999902473 | 0.2810255943 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3116391673 |
| GSE13712_SHEAR | Down | -0.4888740857 |
| GSE13712_STATIC | Down | -0.5422751228 |
| GSE19018 | Down | -0.6934343245 |
| GSE19899_A1 | Down | -0.7792447734 |
| GSE19899_A2 | Down | -0.2957613071 |
| PubMed_21979375_A1 | Down | -0.2848181393 |
| PubMed_21979375_A2 | Down | -0.5247095626 |
| GSE35957 | Down | -0.5192179249 |
| GSE36640 | Down | -0.3057716891 |
| GSE54402 | Up | 0.4273675856 |
| GSE9593 | Down | -0.4717255930 |
| GSE43922 | Up | 0.0821823767 |
| GSE24585 | Up | 0.0725428937 |
| GSE37065 | Down | -0.0161504902 |
| GSE28863_A1 | Down | -0.2306676166 |
| GSE28863_A2 | Up | 0.3971383681 |
| GSE28863_A3 | Down | -0.3305734677 |
| GSE28863_A4 | Up | 0.0321786187 |
| GSE48662 | Down | -0.4507223871 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024847 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026482 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT050039 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
