HCSGD entry for PAX8

1. General information

Official gene symbolPAX8
Entrez ID7849
Gene full namepaired box 8
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0001655Urogenital system developmentISSbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisIEPbiological_process
GO:0001822Kidney developmentIEPbiological_process
GO:0001823Mesonephros developmentISSbiological_process
GO:0003337Mesenchymal to epithelial transition involved in metanephros morphogenesisIEPbiological_process
GO:0003677DNA bindingIDA IMPmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0004996Thyroid-stimulating hormone receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmISScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006351Transcription, DNA-templatedIDAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007417Central nervous system developmentIEPbiological_process
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0030878Thyroid gland developmentIEP IMPbiological_process
GO:0038194Thyroid-stimulating hormone signaling pathwayTASbiological_process
GO:0039003Pronephric field specificationISSbiological_process
GO:0042472Inner ear morphogenesisISSbiological_process
GO:0042981Regulation of apoptotic processISSbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIDA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048793Pronephros developmentISSbiological_process
GO:0071371Cellular response to gonadotropin stimulusIDAbiological_process
GO:0071599Otic vesicle developmentIEPbiological_process
GO:0072108Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisISSbiological_process
GO:0072164Mesonephric tubule developmentIEAbiological_process
GO:0072207Metanephric epithelium developmentIEPbiological_process
GO:0072221Metanephric distal convoluted tubule developmentISSbiological_process
GO:0072278Metanephric comma-shaped body morphogenesisIEPbiological_process
GO:0072284Metanephric S-shaped body morphogenesisIEPbiological_process
GO:0072289Metanephric nephron tubule formationISSbiological_process
GO:0072305Negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesisISSbiological_process
GO:0072307Regulation of metanephric nephron tubule epithelial cell differentiationISSbiological_process
GO:0090190Positive regulation of branching involved in ureteric bud morphogenesisISSbiological_process
GO:1900212Negative regulation of mesenchymal cell apoptotic process involved in metanephros developmentISSbiological_process
GO:1900215Negative regulation of apoptotic process involved in metanephric collecting duct developmentISSbiological_process
GO:1900218Negative regulation of apoptotic process involved in metanephric nephron tubule developmentISSbiological_process
GO:2000594Positive regulation of metanephric DCT cell differentiationISSbiological_process
GO:2000611Positive regulation of thyroid hormone generationIMPbiological_process
GO:2000612Regulation of thyroid-stimulating hormone secretionIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73019962770.80165157480.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0499591960
GSE13712_SHEARDown-0.0015946273
GSE13712_STATICDown-0.0788558742
GSE19018Up0.0242023620
GSE19899_A1Up0.0350908627
GSE19899_A2Up0.1901996173
PubMed_21979375_A1Up0.3037463269
PubMed_21979375_A2Down-0.0994136128
GSE35957Up0.0806110519
GSE36640Down-0.0665100915
GSE54402Up0.1266387539
GSE9593Up0.1110596625
GSE43922Up0.0487738760
GSE24585Down-0.2146960302
GSE37065Up0.0274983116
GSE28863_A1Down-0.0707470473
GSE28863_A2Down-0.0188843148
GSE28863_A3Up0.0792023886
GSE28863_A4Up0.0170300889
GSE48662Down-0.0121814252

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26781745Pax8 plays a pivotal role in regulation of cardiomyocyte growth and senescence
26781745We have recently found that paired box gene 8 (Pax8) may be the downstream molecule of ALK3
26781745We hypothesized that together with various biological processes, such as apoptosis, enhanced cellular senescence may occur actively in the development of Pax8 null mice murine hearts
26781745In H9C2 myogenic cells, Pax8 overexpression can rescue caspase-dependent apoptosis induced by ALK3 silencing
26781745Senescent cells and senescence-associated mediators in Pax8 knockout hearts increased compared with the wild-type ones in an age-dependent manner
26781745These results suggest that Pax8 maybe the downstream molecule of ALK3, it mediates the murine heart development perhaps via cellular senescence, which may serve as a mechanism that compensates for the cell loss via apoptosis in heart development
26236688Only the subcutaneous grafts formed tumors that were negative for cytokeratin, but positive for oviductal markers, such as oviductal glycoprotein 1 and Pax8
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