HCSGD entry for CACNB2
1. General information
| Official gene symbol | CACNB2 |
|---|---|
| Entrez ID | 783 |
| Gene full name | calcium channel, voltage-dependent, beta 2 subunit |
| Other gene symbols | CACNLB2 CAVB2 MYSB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005245 | Voltage-gated calcium channel activity | IDA IEA | molecular_function |
| GO:0005262 | Calcium channel activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005887 | Integral component of plasma membrane | NAS | cellular_component |
| GO:0005891 | Voltage-gated calcium channel complex | IDA IEA | cellular_component |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0007268 | Synaptic transmission | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007528 | Neuromuscular junction development | TAS | biological_process |
| GO:0007601 | Visual perception | IEA | biological_process |
| GO:0008331 | High voltage-gated calcium channel activity | IDA | molecular_function |
| GO:0042383 | Sarcolemma | IEA | cellular_component |
| GO:0051928 | Positive regulation of calcium ion transport | IDA | biological_process |
| GO:0070509 | Calcium ion import | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9288623343 | 0.4053324836 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0101211806 |
| GSE13712_SHEAR | Down | -0.0359380632 |
| GSE13712_STATIC | Down | -0.0490562119 |
| GSE19018 | Up | 0.0579244366 |
| GSE19899_A1 | Up | 0.0418072596 |
| GSE19899_A2 | Down | -0.0418625770 |
| PubMed_21979375_A1 | Down | -0.2237980689 |
| PubMed_21979375_A2 | Down | -0.0388952949 |
| GSE35957 | Down | -0.0434178932 |
| GSE36640 | Down | -0.0559489336 |
| GSE54402 | Down | -0.2381370023 |
| GSE9593 | Up | 0.0964668599 |
| GSE43922 | Down | -0.0343129313 |
| GSE24585 | Up | 0.2126384483 |
| GSE37065 | Down | -0.0961254888 |
| GSE28863_A1 | Up | 0.1575255501 |
| GSE28863_A2 | Down | -0.4253358532 |
| GSE28863_A3 | Up | 0.0085523568 |
| GSE28863_A4 | Down | -0.0046418082 |
| GSE48662 | Down | -0.0046406080 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Isradipine | DB00270 | APRD00298 |
| Nisoldipine | DB00401 | APRD00635 |
| Nicardipine | DB00622 | APRD00088 |
| Magnesium Sulfate | DB00653 | APRD01080 |
| Verapamil | DB00661 | APRD00335 |
| Nitrendipine | DB01054 | APRD00421 |
| Nifedipine | DB01115 | APRD00590 |
| Mibefradil | DB01388 | - |
| Dronedarone | DB04855 | - |
| Nilvadipine | DB06712 | - |
| Spironolactone | DB00421 | APRD01234 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029034 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051063 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
