HCSGD entry for DAP3
1. General information
| Official gene symbol | DAP3 |
|---|---|
| Entrez ID | 7818 |
| Gene full name | death associated protein 3 |
| Other gene symbols | DAP-3 MRP-S29 MRPS29 bMRP-10 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005761 | Mitochondrial ribosome | IEA | cellular_component |
| GO:0008637 | Apoptotic mitochondrial changes | IEA | biological_process |
| GO:0015935 | Small ribosomal subunit | IEA | cellular_component |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0719633753 | 0.9509945177 | 0.5715393848 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4058854329 |
| GSE13712_SHEAR | Up | 0.0978397276 |
| GSE13712_STATIC | Down | -0.0018793584 |
| GSE19018 | Up | 0.0858824841 |
| GSE19899_A1 | Up | 0.3857933923 |
| GSE19899_A2 | Up | 0.3083627528 |
| PubMed_21979375_A1 | Down | -0.0867526839 |
| PubMed_21979375_A2 | Up | 0.1057552471 |
| GSE35957 | Up | 0.1371821329 |
| GSE36640 | Up | 0.2921215582 |
| GSE54402 | Up | 0.3570566620 |
| GSE9593 | Down | -0.1488916093 |
| GSE43922 | Up | 0.1406135972 |
| GSE24585 | Up | 0.2179429759 |
| GSE37065 | Down | -0.1788881002 |
| GSE28863_A1 | Up | 0.4689778329 |
| GSE28863_A2 | Up | 0.6254333374 |
| GSE28863_A3 | Down | -0.0265749975 |
| GSE28863_A4 | Down | -0.1364360284 |
| GSE48662 | Down | -0.3300714547 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031739 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031739 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036140 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040466 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043117 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044320 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17056041 | Death-associated protein 3 (DAP3) has been originally identified as a positive mediator of apoptosis |
| 17056041 | Death-associated protein 3 (DAP3) has been originally identified as a positive mediator of apoptosis |
| 17056041 | It has been revealed recently that the predominant localization of DAP3 to mitochondria implies its functional involvement in mitochondrial metabolism in addition to apoptosis |
| 17056041 | However, little is known about the molecular basis of these physiological functions of DAP3 |
| 17056041 | Here, we demonstrate that DAP3 is reduced in both replicative and premature senescence induced by oxidative stress, and the DAP3 reduction induced by oxidative stress is observed mostly in a mitochondrial fraction |
| 17056041 | Here, we demonstrate that DAP3 is reduced in both replicative and premature senescence induced by oxidative stress, and the DAP3 reduction induced by oxidative stress is observed mostly in a mitochondrial fraction |
| 17056041 | Using DAP3-specific short hairpin RNA (shRNA) in a clonogenic survival assay, we reveal that reduction of DAP3 induces resistance to oxidative stress and decreases intracellular reactive oxygen species (ROS) production |
| 17056041 | Furthermore, this strategy allows us to show that loss of DAP3 is involved in the avoidance of replicative senescence in mouse embryonic fibroblasts (MEFs) |
| 17056041 | Thus, our study offers an insight into the potential regulatory function of mitochondrial DAP3 involved in cellular senescence |
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