HCSGD entry for CACNA2D1
1. General information
| Official gene symbol | CACNA2D1 |
|---|---|
| Entrez ID | 781 |
| Gene full name | calcium channel, voltage-dependent, alpha 2/delta subunit 1 |
| Other gene symbols | CACNA2 CACNL2A CCHL2A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005245 | Voltage-gated calcium channel activity | IDA | molecular_function |
| GO:0005891 | Voltage-gated calcium channel complex | IDA | cellular_component |
| GO:0006816 | Calcium ion transport | IDA | biological_process |
| GO:0016529 | Sarcoplasmic reticulum | IEA | cellular_component |
| GO:0030315 | T-tubule | IEA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051924 | Regulation of calcium ion transport | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1284682763 | 0.1264367805 | 0.7280451668 | 0.6847618313 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0190722622 |
| GSE13712_SHEAR | Up | 0.2366077185 |
| GSE13712_STATIC | Up | 0.0820990993 |
| GSE19018 | Up | 0.1544522215 |
| GSE19899_A1 | Down | -0.1649279959 |
| GSE19899_A2 | Down | -0.4617201873 |
| PubMed_21979375_A1 | Down | -0.5416150254 |
| PubMed_21979375_A2 | Down | -0.2553124931 |
| GSE35957 | Up | 0.2290988625 |
| GSE36640 | Up | 1.3096860428 |
| GSE54402 | Down | -0.7558109744 |
| GSE9593 | Up | 0.0917209831 |
| GSE43922 | Down | -0.0324593302 |
| GSE24585 | Down | -0.4273793005 |
| GSE37065 | Down | -0.4875089429 |
| GSE28863_A1 | Up | 0.6023176132 |
| GSE28863_A2 | Up | 0.6793088660 |
| GSE28863_A3 | Up | 0.0065376088 |
| GSE28863_A4 | Down | -0.1217205901 |
| GSE48662 | Up | 0.6540974993 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Isradipine | DB00270 | APRD00298 |
| Ibutilide | DB00308 | APRD01025 |
| Nisoldipine | DB00401 | APRD00635 |
| Nicardipine | DB00622 | APRD00088 |
| Magnesium Sulfate | DB00653 | APRD01080 |
| Gabapentin | DB00996 | APRD00015 |
| Nitrendipine | DB01054 | APRD00421 |
| Nifedipine | DB01115 | APRD00590 |
| Cyclandelate | DB04838 | - |
| XP13512 | DB04922 | - |
| Nilvadipine | DB06712 | - |
| Spironolactone | DB00421 | APRD01234 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001474 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023627 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
