HCSGD entry for LRP8
1. General information
| Official gene symbol | LRP8 |
|---|---|
| Entrez ID | 7804 |
| Gene full name | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor |
| Other gene symbols | APOER2 HSZ75190 LRP-8 MCI1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0001523 | Retinoid metabolic process | TAS | biological_process |
| GO:0004888 | Transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005875 | Microtubule associated complex | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005901 | Caveola | IDA | cellular_component |
| GO:0006508 | Proteolysis | NAS | biological_process |
| GO:0006629 | Lipid metabolic process | NAS | biological_process |
| GO:0006897 | Endocytosis | IDA | biological_process |
| GO:0006898 | Receptor-mediated endocytosis | IDA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0007603 | Phototransduction, visible light | TAS | biological_process |
| GO:0008035 | High-density lipoprotein particle binding | IEA | molecular_function |
| GO:0014069 | Postsynaptic density | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IC IEA | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | NAS | biological_process |
| GO:0019894 | Kinesin binding | IEA | molecular_function |
| GO:0021541 | Ammon gyrus development | ISS | biological_process |
| GO:0021819 | Layer formation in cerebral cortex | IEA | biological_process |
| GO:0030229 | Very-low-density lipoprotein particle receptor activity | IDA | molecular_function |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0032793 | Positive regulation of CREB transcription factor activity | ISS | biological_process |
| GO:0034185 | Apolipoprotein binding | IC | molecular_function |
| GO:0038025 | Reelin receptor activity | ISS | molecular_function |
| GO:0038026 | Reelin-mediated signaling pathway | ISS | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | ISS | biological_process |
| GO:0050804 | Regulation of synaptic transmission | ISS | biological_process |
| GO:0061003 | Positive regulation of dendritic spine morphogenesis | ISS | biological_process |
| GO:0061098 | Positive regulation of protein tyrosine kinase activity | ISS | biological_process |
| GO:0071363 | Cellular response to growth factor stimulus | IEA | biological_process |
| GO:0071397 | Cellular response to cholesterol | IEA | biological_process |
| GO:1900006 | Positive regulation of dendrite development | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1259591847 | 0.0237643897 | 0.7236177099 | 0.2974760818 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5613837172 |
| GSE13712_SHEAR | Down | -0.3230134083 |
| GSE13712_STATIC | Up | 0.4537273354 |
| GSE19018 | Down | -0.2366666190 |
| GSE19899_A1 | Down | -0.0450393531 |
| GSE19899_A2 | Down | -0.4578092899 |
| PubMed_21979375_A1 | Down | -0.8252971810 |
| PubMed_21979375_A2 | Down | -0.6343769444 |
| GSE35957 | Down | -0.8523145452 |
| GSE36640 | Up | 1.1114514624 |
| GSE54402 | Up | 1.0652270699 |
| GSE9593 | Down | -0.0530550945 |
| GSE43922 | Down | -0.0589026729 |
| GSE24585 | Down | -0.7856854628 |
| GSE37065 | Up | 0.4165278250 |
| GSE28863_A1 | Down | -0.4740724999 |
| GSE28863_A2 | Up | 0.9247348699 |
| GSE28863_A3 | Down | -0.5984415740 |
| GSE28863_A4 | Up | 0.1044352804 |
| GSE48662 | Down | -0.5505879211 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020152 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024366 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026507 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031127 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT046111 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
