HCSGD entry for DDR1

1. General information

Official gene symbolDDR1
Entrez ID780
Gene full namediscoidin domain receptor tyrosine kinase 1
Other gene symbolsCAK CD167 DDR EDDR1 HGK2 MCK10 NEP NTRK4 PTK3 PTK3A RTK6 TRKE
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001558Regulation of cell growthIEAbiological_process
GO:0001952Regulation of cell-matrix adhesionIEAbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004714Transmembrane receptor protein tyrosine kinase activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005518Collagen bindingIDA IEA IMPmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007155Cell adhesionIEA TASbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayIEAbiological_process
GO:0007566Embryo implantationIEAbiological_process
GO:0007595LactationIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0010715Regulation of extracellular matrix disassemblyIEA IMPbiological_process
GO:0014909Smooth muscle cell migrationIEA IMPbiological_process
GO:0016020MembraneIEAcellular_component
GO:0018108Peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0038062Protein tyrosine kinase collagen receptor activityIDAmolecular_function
GO:0038063Collagen-activated tyrosine kinase receptor signaling pathwayIDA IEA IMPbiological_process
GO:0038083Peptidyl-tyrosine autophosphorylationIDAbiological_process
GO:0043235Receptor complexIDAcellular_component
GO:0043583Ear developmentIEAbiological_process
GO:0044319Wound healing, spreading of cellsIEA IMPbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0060444Branching involved in mammary gland duct morphogenesisIEAbiological_process
GO:0060749Mammary gland alveolus developmentIEAbiological_process
GO:0061302Smooth muscle cell-matrix adhesionIEA IMPbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09330167170.99723243800.64055446011.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.2665881325

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ImatinibDB00619 APRD01028 | EXPT02967 | DB03261

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-199a-5pMIMAT0000231MIRT004674Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20799954
hsa-miR-335-5pMIMAT0000765MIRT017205MicroarrayFunctional MTI (Weak)18185580
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.