HCSGD entry for MAP3K12
1. General information
| Official gene symbol | MAP3K12 |
|---|---|
| Entrez ID | 7786 |
| Gene full name | mitogen-activated protein kinase kinase kinase 12 |
| Other gene symbols | DLK MEKK12 MUK ZPK ZPKP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA ISS | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | IEA ISS | cellular_component |
| GO:0005886 | Plasma membrane | IEA ISS | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA ISS | biological_process |
| GO:0007254 | JNK cascade | ISS | biological_process |
| GO:0016020 | Membrane | ISS | cellular_component |
| GO:0016572 | Histone phosphorylation | IEA ISS | biological_process |
| GO:0018105 | Peptidyl-serine phosphorylation | IEA ISS | biological_process |
| GO:0018107 | Peptidyl-threonine phosphorylation | IEA ISS | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0030426 | Growth cone | IEA | cellular_component |
| GO:0035556 | Intracellular signal transduction | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA ISS | molecular_function |
| GO:0046777 | Protein autophosphorylation | IEA ISS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1044355002 | 0.3851837012 | 0.6715970682 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2295516987 |
| GSE13712_SHEAR | Down | -0.5953605573 |
| GSE13712_STATIC | Down | -0.4935847777 |
| GSE19018 | Down | -0.2813642074 |
| GSE19899_A1 | Up | 0.0350227756 |
| GSE19899_A2 | Up | 0.4499001526 |
| PubMed_21979375_A1 | Up | 0.1366278752 |
| PubMed_21979375_A2 | Up | 0.7020972439 |
| GSE35957 | Down | -0.1211427756 |
| GSE36640 | Up | 0.6119329280 |
| GSE54402 | Up | 0.1942355781 |
| GSE9593 | Up | 0.3115079569 |
| GSE43922 | Up | 0.0672641320 |
| GSE24585 | Up | 0.8354907473 |
| GSE37065 | Up | 0.0089015042 |
| GSE28863_A1 | Up | 0.3093449283 |
| GSE28863_A2 | Down | -0.1606056177 |
| GSE28863_A3 | Down | -0.4048161685 |
| GSE28863_A4 | Down | -0.3712292773 |
| GSE48662 | Down | -0.0002501389 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-20a-5p | MIMAT0000075 | MIRT003010 | Luciferase reporter assay | Functional MTI | 19666108 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT003013 | Luciferase reporter assay | Functional MTI | 19666108 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029590 | Microarray | Functional MTI (Weak) | 19088304 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
