HCSGD entry for ZBTB17
1. General information
| Official gene symbol | ZBTB17 |
|---|---|
| Entrez ID | 7709 |
| Gene full name | zinc finger and BTB domain containing 17 |
| Other gene symbols | MIZ-1 ZNF151 ZNF60 pHZ-67 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001702 | Gastrulation with mouth forming second | IEA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0007398 | Ectoderm development | IEA | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045786 | Negative regulation of cell cycle | TAS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3717368489 | 0.9110914707 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0872519391 |
| GSE13712_SHEAR | Down | -0.0479749860 |
| GSE13712_STATIC | Up | 0.0778162235 |
| GSE19018 | Up | 0.1272360867 |
| GSE19899_A1 | Down | -0.0021793945 |
| GSE19899_A2 | Up | 0.2167604787 |
| PubMed_21979375_A1 | Up | 0.2541121686 |
| PubMed_21979375_A2 | Up | 0.3350807594 |
| GSE35957 | Down | -0.3271642903 |
| GSE36640 | Down | -0.0671381065 |
| GSE54402 | Up | 0.1034290164 |
| GSE9593 | Down | -0.1349642884 |
| GSE43922 | Up | 0.1717653836 |
| GSE24585 | Down | -0.0237160257 |
| GSE37065 | Up | 0.0119600558 |
| GSE28863_A1 | Up | 0.0241527881 |
| GSE28863_A2 | Up | 0.1038366476 |
| GSE28863_A3 | Up | 0.0428352522 |
| GSE28863_A4 | Down | -0.0026660617 |
| GSE48662 | Up | 0.3747493341 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16380648 | Previous studies showed that ECRG1 overexpression could inhibit cell growth and induce G1 cell cycle arrest and p15(INK4b) expression by interacting with Miz-1 (Myc-interacting zinc finger protein) |
| 16167342 | We have located an initiator element (Inr), a candidate for Miz-1 binding, in the hMad4 promoter |
| 16167342 | In reporter assays, Miz-1 enhances reporter GFP expression; this enhancement is inhibited by co-expressing c-Myc |
| 16167342 | Thus hMad4, as does its murine counterpart, contains the Inr element through which Miz-1 activates its expression; but this action is inhibited in the presence of c-Myc |
| 16167342 | Our results suggest that: (1) replicative senescence-specific factors may block c-Myc inhibition of Miz-1 activation of hMad4 expression; and (2) the continual presence of hMad4 protein may transcriptionally repress selected c-Myc target genes, whose functions are key to the signaling pathways leading to apoptosis inhibition and permanent exit of cell cycle traverse in normal human fibroblasts |
| 11846374 | Moreover, quiescence and senescence can be distinguished by increased expression of Irlb, c-Myc transcription factor, and Miz-1, c-Myc-interacting Zn finger protein 1, only in the former state |
| 11283613 | Here we show that a Myc-associated transcription factor, Miz-1, arrests cells in G1 phase and inhibits cyclin D-associated kinase activity |
| 11283613 | Miz-1 upregulates expression of the cyclin-dependent kinases (CDK) inhibitor p15INK4b by binding to the initiator element of the p15INK4b promoter |
| 11283613 | Alleles of c-myc that are unable to bind to Miz-1 fail to inhibit accumulation of p15INK4b messenger RNA in primary cells and are, as a consequence, deficient in immortalization |
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